Linked Life Data

7904781

Source:http://linkedlifedata.com/resource/pubmed/id/7904781

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-2-18
pubmed:abstractText
NAD has been studied for its effect on the uptake of serotonin, norepinephrine, dopamine and GABA by synaptic vesicles. It has been shown that norepinephrine and dopamine uptake is not altered by addition of 10(-3) M, 10(-6) M, 10(-8) M, 10(-9) M and 10(-12) M NAD concentrations to incubation medium while the serotonin uptake is increased by 29, 47, 23, 24 and 18%, respectively. 10(-3) M and 10(-6) M NAD concentrations decrease GABA uptake by 30% and 24%. The study of 10(-6) M NAD effect on serotonin release from serotonin pre-loaded vesicles demonstrated the marked elevation of the neurotransmitter release, especially during the first 4 minutes of incubation (by 40%). The similar effect on serotonin release, is observed after addition of KCl, standard depolarizing agent, to the incubation medium. In contrast to synaptic membranes, the red blood cell membranes did not activate the neurotransmitter release after addition of serotonin pre-loaded vesicles to incubation medium, which proves the specificity of synaptic vesicles--synaptic membranes interaction. The modulating NAD action at the presynaptic membrane level can also be assumed.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0201-8470
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
66-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Effect of NAD on uptake and release of some mediators by synaptic vesicles of the rat's brain].
pubmed:publicationType
Journal Article, English Abstract