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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1994-2-10
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pubmed:abstractText |
The effects of a number of psycho-active drugs on electrocorticographic activity (ECoG) of the rat have been studied. Frontoparietal ECoG was recorded during 6-min periods immediately before drug/vehicle administration and starting at 20 and 45 min after administration. For each 6-min recording time, a mean power spectrum was calculated and smoothed. A quotient of the power at 20 and 45 min after and before drug, respectively, was then calculated. These quotients were used as input for an analysis of variance, followed by a t test and a normalization for the degrees of freedom, resulting in so-called n-profiles. Although each drug has its own characteristic n-profile, n-profiles of drugs belonging to the same clinical class have some characteristics in common. An automated classification system of psychotropic drugs, based on parameters extracted from n-profiles by discriminant analysis, is presented. For the antidepressant drug class the success rate of correct classification of antidepressant drugs is between 53 and 88%, for a neuroleptic drug in the neuroleptic drug class the success rate is 87%, for an anxiolytic drug in the anxiolytic drug class 100% and for a psychostimulant drug in the psychostimulant drug class between 86 and 100%. For a reliable classification of a drug about 10 n-profiles of active doses are needed. Using n-profiles, it appeared also possible to discriminate between antidepressant, neuroleptic, anxiolytic and psychostimulant drugs based on visual judgement. Moreover, visual evaluation of the n-profiles enables 4 subclasses to be recognized within the antidepressant class, 2 subclasses within the neuroleptic and 2 subclasses within the anxiolytic class.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Anxiety Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antipsychotic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Central Nervous System Stimulants,
http://linkedlifedata.com/resource/pubmed/chemical/Psychotropic Drugs
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pubmed:status |
MEDLINE
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pubmed:issn |
0302-282X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
122-37
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:7904054-Animals,
pubmed-meshheading:7904054-Anti-Anxiety Agents,
pubmed-meshheading:7904054-Antidepressive Agents,
pubmed-meshheading:7904054-Antipsychotic Agents,
pubmed-meshheading:7904054-Arousal,
pubmed-meshheading:7904054-Central Nervous System Stimulants,
pubmed-meshheading:7904054-Electroencephalography,
pubmed-meshheading:7904054-Male,
pubmed-meshheading:7904054-Psychotropic Drugs,
pubmed-meshheading:7904054-Rats,
pubmed-meshheading:7904054-Rats, Wistar
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pubmed:year |
1993
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pubmed:articleTitle |
Classification of psychotropic drugs based on pharmaco-electrocorticographic studies in vigilance-controlled rats.
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pubmed:affiliation |
Department of CNS Pharmacology, Weesp, The Netherlands.
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pubmed:publicationType |
Journal Article
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