rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
11
|
pubmed:dateCreated |
1994-2-7
|
pubmed:abstractText |
Intrathymic T-cell differentiation involves the generation, expansion and selection of distinct T-lymphocyte subsets. While positive and negative selection have been a focal point of T-cell development, these events represent the final stages in a complicated sequence of differentiation steps. Here, Dale Godfrey and Albert Zlotnik summarize recent advances in our understanding of early T-cell development and describe five 'control points' that identify key events in this sequence.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0167-5699
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
547-53
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:7903854-Animals,
pubmed-meshheading:7903854-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7903854-Cell Differentiation,
pubmed-meshheading:7903854-Gene Rearrangement, T-Lymphocyte,
pubmed-meshheading:7903854-Humans,
pubmed-meshheading:7903854-Lymphocyte Activation,
pubmed-meshheading:7903854-Mice,
pubmed-meshheading:7903854-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:7903854-T-Lymphocytes,
pubmed-meshheading:7903854-T-Lymphocytes, Regulatory,
pubmed-meshheading:7903854-Thymus Gland
|
pubmed:year |
1993
|
pubmed:articleTitle |
Control points in early T-cell development.
|
pubmed:affiliation |
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304.
|
pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|