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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1994-2-7
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pubmed:abstractText |
Intrathymic T-cell differentiation involves the generation, expansion and selection of distinct T-lymphocyte subsets. While positive and negative selection have been a focal point of T-cell development, these events represent the final stages in a complicated sequence of differentiation steps. Here, Dale Godfrey and Albert Zlotnik summarize recent advances in our understanding of early T-cell development and describe five 'control points' that identify key events in this sequence.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0167-5699
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
547-53
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7903854-Animals,
pubmed-meshheading:7903854-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7903854-Cell Differentiation,
pubmed-meshheading:7903854-Gene Rearrangement, T-Lymphocyte,
pubmed-meshheading:7903854-Humans,
pubmed-meshheading:7903854-Lymphocyte Activation,
pubmed-meshheading:7903854-Mice,
pubmed-meshheading:7903854-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:7903854-T-Lymphocytes,
pubmed-meshheading:7903854-T-Lymphocytes, Regulatory,
pubmed-meshheading:7903854-Thymus Gland
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pubmed:year |
1993
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pubmed:articleTitle |
Control points in early T-cell development.
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pubmed:affiliation |
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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