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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-2-2
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pubmed:abstractText |
Indefinite graft survival was obtained with murine cardiac allografts using the combined administration of monoclonal antibodies (mAbs) directed against the receptor ligand pair CD2-CD48. Although each antibody could prolong graft survival when given alone, neither resulted in the indefinite graft survival seen with the combination. Combined mAb administration is associated with inhibition of T cell priming and help and subsequent cytotoxic T lymphocyte generation. This indicates that the interaction between CD2 and its ligand is important for antigen priming and recognition, and combined mAbs may prove to be a useful therapeutic regimen for transplantation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-1082897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-1347662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-1353913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-1358605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-1377404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-1383383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-1385156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-14061262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-1670971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-1682413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-1699884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-1860621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-1974032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-2483402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-2564824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-2576417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-2647894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-2683262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-310861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-4934264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-6287003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-8097344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-8468465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-8475091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7903681-92524
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD2,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD48 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
179
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
341-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7903681-Animals,
pubmed-meshheading:7903681-Antibodies, Monoclonal,
pubmed-meshheading:7903681-Antigens, CD,
pubmed-meshheading:7903681-Antigens, CD2,
pubmed-meshheading:7903681-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:7903681-Drug Synergism,
pubmed-meshheading:7903681-Female,
pubmed-meshheading:7903681-Graft Survival,
pubmed-meshheading:7903681-Heart Transplantation,
pubmed-meshheading:7903681-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:7903681-Mice,
pubmed-meshheading:7903681-Mice, Inbred BALB C,
pubmed-meshheading:7903681-Mice, Inbred C57BL,
pubmed-meshheading:7903681-Mice, Inbred CBA,
pubmed-meshheading:7903681-Receptors, Immunologic,
pubmed-meshheading:7903681-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:7903681-Transplantation, Homologous
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pubmed:year |
1994
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pubmed:articleTitle |
Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival.
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pubmed:affiliation |
Department of Surgery, Medical University of South Carolina, Charleston 29425.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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