Linked Life Data

7903372

Source:http://linkedlifedata.com/resource/pubmed/id/7903372

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1994-1-24
pubmed:abstractText
Cyclosporin A pharmacokinetics were studied following intravenous and abomasal dosing in an open, crossover study in healthy, merino ewes. Five different doses of cyclosporin A were dispersed in milk and administered into the abomasum through a surgically inserted fistula which simulates oral administration. Cyclosporin A was well tolerated. Whole blood concentrations of cyclosporin A were measured by HPLC and mean clearance (0.45 +/- 0.05 L h-1 kg-1), distribution volume (4.4 +/- 2.0 L kg-1), mean residence time (9.6 +/- 4.1 h) and half-life (12.1 +/- 3.1 h) were calculated cyclosporin A was excreted in urine or bile. Area under the curve increased proportionally with doses up to 26.3 mg kg-1, but was curvilinear above this dose. Abomasal bioavailability at 6.4 mg kg-1 was 0.26 +/- 0.09, and mean absorption time was 4.7 +/- 11.1 h. Considerable pharmacokinetic variability was observed, particularly after abomasal administration. Cyclosporin A pharmacokinetics in sheep lie within the values reported in man after renal, bone marrow and cardiac transplantation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-3573
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
821-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Pharmacokinetics and absolute bioavailability of cyclosporin following intravenous and abomasal administration to sheep.
pubmed:affiliation
Department of Pharmacy, University of Queensland, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't