Linked Life Data

7902904

Source:http://linkedlifedata.com/resource/pubmed/id/7902904

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8886-8887
pubmed:dateCreated
1994-1-12
pubmed:abstractText
Reduced intra-tumoral drug concentrations have been investigated as a mechanism of tamoxifen resistance in 51 patients with locally recurrent breast cancer. Serum tamoxifen was similar in patients with acquired and de-novo resistance, but intra-tumoral concentrations were significantly lower in patients with acquired resistance. Tumour oestrogen-receptor concentrations at relapse did not support the hypothesis that selective outgrowth of oestrogen-receptor-negative cells is a major mechanism for acquired tamoxifen resistance. Reduced intra-tumoral tamoxifen levels during prolonged therapy may be an important mechanism for acquired resistance in breast cancer.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0140-6736
pubmed:author
pubmed:issnType
Print
pubmed:volume
342
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1521-2
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Acquired tamoxifen resistance in human breast cancer and reduced intra-tumoral drug concentration.
pubmed:affiliation
Academic Department of Biochemistry, Royal Marsden Hospital, London, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't