Linked Life Data

7902903

Source:http://linkedlifedata.com/resource/pubmed/id/7902903

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8886-8887
pubmed:dateCreated
1994-1-12
pubmed:abstractText
Tobacco smoke contains many carcinogens and has been linked with the development of lung cancer. We sequenced the conserved regions of the p53 tumour suppressor gene in lung cancers from 17 non-smokers from Hiroshima, Japan; 9 were atomic-bomb survivors. The mutations were predominantly transitions (all G:C to A:T); there were no G:C to T:A transversions. By contrast, lung cancers from 77 Japanese smokers have a predominance of G:C to T:A transversions in which the guanine residues occur on the non-transcribed DNA strand. These findings further implicate tobacco smoke carcinogens in the molecular pathogenesis of lung cancer.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:issn
0140-6736
pubmed:author
pubmed:issnType
Print
pubmed:volume
342
pubmed:geneSymbol
genes, p53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1520-1
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
p53 mutations in lung cancers from non-smoking atomic-bomb survivors.
pubmed:affiliation
National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.