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rdf:type |
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lifeskim:mentions |
umls-concept:C0006556,
umls-concept:C0009017,
umls-concept:C0017262,
umls-concept:C0071163,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205245,
umls-concept:C0597357,
umls-concept:C0679058,
umls-concept:C1547699,
umls-concept:C2700640,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
1994-1-4
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pubmed:databankReference |
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pubmed:abstractText |
A functional cDNA clone for a human pituitary adenylate cyclase activating polypeptide (PACAP) receptor was isolated from a human pituitary cDNA library. The cDNA encoded a polypeptide consisting of 525 amino acids with putative seven hydrophobic domains. Chinese hamster ovary (CHO)-K1 cells transfected with the cDNA specifically bound PACAP and mediated PACAP-triggered intracellular accumulation of cAMP, indicating that this cDNA encoded a functional human PACAP Type I receptor. This receptor was structurally related to the vasoactive intestinal peptide (VIP), secretin, calcitonin and parathyroid hormone receptors and is much more homologous to a rat PACAP receptor. Northern blot analysis revealed that PACAP receptor mRNAs were expressed mainly in the brain and widely distributed in the central nervous system.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADCYAP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Adcyap1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotransmitter Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotide Probes,
http://linkedlifedata.com/resource/pubmed/chemical/Pituitary Adenylate...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Pituitary Adenylate...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Pituitary Adenylate...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Pituitary Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoactive Intestinal Peptide
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
196
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1511-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7902709-Amino Acid Sequence,
pubmed-meshheading:7902709-Animals,
pubmed-meshheading:7902709-Base Sequence,
pubmed-meshheading:7902709-Blotting, Northern,
pubmed-meshheading:7902709-Blotting, Southern,
pubmed-meshheading:7902709-CHO Cells,
pubmed-meshheading:7902709-Cell Membrane,
pubmed-meshheading:7902709-Cloning, Molecular,
pubmed-meshheading:7902709-Cricetinae,
pubmed-meshheading:7902709-Cyclic AMP,
pubmed-meshheading:7902709-DNA, Complementary,
pubmed-meshheading:7902709-Gene Expression,
pubmed-meshheading:7902709-Gene Library,
pubmed-meshheading:7902709-Humans,
pubmed-meshheading:7902709-Kinetics,
pubmed-meshheading:7902709-Molecular Sequence Data,
pubmed-meshheading:7902709-Neuropeptides,
pubmed-meshheading:7902709-Neurotransmitter Agents,
pubmed-meshheading:7902709-Oligonucleotide Probes,
pubmed-meshheading:7902709-Pituitary Adenylate Cyclase-Activating Polypeptide,
pubmed-meshheading:7902709-Pituitary Gland,
pubmed-meshheading:7902709-Protein Conformation,
pubmed-meshheading:7902709-Rats,
pubmed-meshheading:7902709-Receptors, Pituitary Adenylate Cyclase-Activating...,
pubmed-meshheading:7902709-Receptors, Pituitary Adenylate Cyclase-Activating...,
pubmed-meshheading:7902709-Receptors, Pituitary Hormone,
pubmed-meshheading:7902709-Sequence Homology, Amino Acid,
pubmed-meshheading:7902709-Transfection,
pubmed-meshheading:7902709-Vasoactive Intestinal Peptide
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pubmed:year |
1993
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pubmed:articleTitle |
Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor.
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pubmed:affiliation |
Discovery Research Laboratories I, Takeda Chemical Industries Ltd., Ibaraki, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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