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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1993-12-28
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pubmed:abstractText |
Sublobular nodules of hepatocytes free of iron or exhibiting much less iron than the surrounding parenchyma, referred to in this study as iron-free-foci, are frequently found in the livers of patients with genetic hemochromatosis complicated by hepatocellular carcinoma. To test the hypothesis that such nodules are preneoplastic lesions, iron-free foci were sought in the initial liver biopsy specimens of 185 patients with untreated and uncomplicated genetic hemochromatosis. Iron-free foci were found in 14 (7.6%) patients, all men, aged from 38 to 76 yr, with heavy iron overload and with fibrosis or cirrhosis. Twelve patients with iron-free foci were followed for 0.9 to 15 yr (7 +/- 6 yr). In six (50%), HCC developed, compared with 2 (8%) from a control group consisting of 24 patients without IFF matched according to age, sex, degree of fibrosis, liver iron amount and follow-up duration. The mean number of iron-free foci per iron-free foci-positive specimen was 3.2 +/- 2.1. Ten patients had dysplastic aspects in their iron-free foci, and four had intrahepatocytic iron-positive inclusions at the periphery of iron-free foci. Proliferative cell nuclear antigen was positive in 75% of iron-free foci and in 24% +/- 21% of hepatocyte nuclei in iron-free foci. This study clearly demonstrates that iron-free foci are proliferative lesions and strongly suggests that such nodules are preneoplastic foci. Therefore the finding of IFF in the initial liver biopsy specimen from a patient with genetic hemochromatosis should lead to regular screening for hepatocellular carcinoma.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0270-9139
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1363-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7902316-Adult,
pubmed-meshheading:7902316-Aged,
pubmed-meshheading:7902316-Carcinoma, Hepatocellular,
pubmed-meshheading:7902316-Follow-Up Studies,
pubmed-meshheading:7902316-Hemochromatosis,
pubmed-meshheading:7902316-Humans,
pubmed-meshheading:7902316-Iron,
pubmed-meshheading:7902316-Liver,
pubmed-meshheading:7902316-Liver Neoplasms,
pubmed-meshheading:7902316-Male,
pubmed-meshheading:7902316-Middle Aged,
pubmed-meshheading:7902316-Nuclear Proteins,
pubmed-meshheading:7902316-Precancerous Conditions,
pubmed-meshheading:7902316-Proliferating Cell Nuclear Antigen
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pubmed:year |
1993
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pubmed:articleTitle |
Preneoplastic significance of hepatic iron-free foci in genetic hemochromatosis: a study of 185 patients.
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pubmed:affiliation |
Clinique des Maladies du Foie, Centre Hospitalier Régional et Universitaire, Rennes, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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