Linked Life Data

7902246

Source:http://linkedlifedata.com/resource/pubmed/id/7902246

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-12-28
pubmed:abstractText
Previously, we have shown that 30 min after S-(6-purinyl)-L-cysteine (PC; 0.13 or 0.4 mmol/kg, ip) treatment of rats, kidney concentrations of 6-mercaptopurine (6-MP) and its further metabolites, 6-methylmercaptopurine and 6-thiouric acid, were nearly 2.4-fold higher than those in liver, and were nearly 90-fold higher than those in plasma. 6-MP was also detected in the urine of rats given the PC analogs, S-(6-purinyl)-N-acetyl-L-cysteine (NAPC), S-(6-purinyl)glutathione (PG), and S-(6-purinyl)-L-homocysteine (PHC). In this study, the kidney-selectivity of the PC analogs was investigated by determining the concentrations of 6-MP and its further metabolites in the kidney, liver, and plasma of rats given the analogs. After NAPC, PG, and PHC (0.8 mmol/kg, ip) treatments, kidney concentrations of total metabolites at 30 min were nearly 17.6-, 6.5-, and 2.9-fold higher than those in liver, respectively. Only trace amounts of metabolites were detected in plasma with any analog. After NAPC treatment (0.8 mmol/kg, ip) total metabolite concentrations in the kidney at 30 min were higher than those detected at 60 or 90 min. When the PC analogs were given at a lower dose (0.4 mmol/kg), only trace amounts of metabolites were detected in the kidney, and no metabolites were detected in liver or plasma. Rates of in vitro metabolism of PHC, PG, and NAPC to 6-MP by kidney homogenates were nearly 10.0, 6.7, and 0.3% of that measured with PC, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0090-9556
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
841-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Targeting of 6-mercaptopurine to the kidneys. Metabolism and kidney-selectivity of S-(6-purinyl)-L-cysteine analogs in rats.
pubmed:affiliation
Department of Comparative Biosciences, University of Wisconsin-Madison.
pubmed:publicationType
Journal Article, Comparative Study