Linked Life Data

7901936

Source:http://linkedlifedata.com/resource/pubmed/id/7901936

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1993-12-14
pubmed:abstractText
A leukocyte adhesion deficiency characterized by recurrent (predominantly bacterial) infections, lack of extravascular polymorphonuclear leukocyte (PMN) and pus formation has been described first in humans and then in dogs, and recently also in cattle. Because of important clinical similarities, a unitary explanation for the leukocyte adhesion deficiency (LAD) syndrome in mammals is proposed, inasmuch that an intrinsic leukocyte defect (i.e. mutations in genes encoding the common CD18 subunit), is thought to cause the disease. However, thus far, the hallmark of such intrinsic leukocyte defects, notably their heritability (or familial incidence), has not (yet) been unequivocally demonstrated. This is the first report to describe the occurrence of four Dutch bovine LAD (BLAD) cases with the clearest familial clustering observed to date. The diagnosis was based on the clinical features of very poor thriving, in general, of the calves, hyperneutrocytosis without appreciable left shift, and the absence of PMN CD11a, or CD11b, or CD11c using monoclonal antibodies (mAb) and/or Concanavalin A binding activity of PMN lysates in immunoblots. Interestingly, a familial clustering was observed also for below-normal PMN CD11c expression. Thus, a cow with low CD11c expression (50.4%) and delivering three of the study BLAD calves, also had a healthy descendant with low (44.9%) PMN CD11c expression. These findings suggested the possibility that both subnormal expression and lack of PMN CD11 expression are inheritable factors in cattle. Furthermore, a large prospective study using the present mAb for selecting relatives expressing the complete spectrum (0 to > or = 90%) of PMN CD11/CD18 expression would create a comprehensive study population for understanding both the role of genetic factors and of survival strategies in BLAD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0165-2427
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
295-308
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Leukocyte adhesion deficiency in a Dutch Holstein calf: a case with a clear-cut family history.
pubmed:affiliation
Department of Immunology, Faculty of Veterinary Medicine, Utrecht, Netherlands.
pubmed:publicationType
Journal Article, Case Reports