| pubmed-article:7901425 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7901425 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7901425 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:7901425 | lifeskim:mentions | umls-concept:C0017431 | lld:lifeskim |
| pubmed-article:7901425 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:7901425 | lifeskim:mentions | umls-concept:C0919425 | lld:lifeskim |
| pubmed-article:7901425 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:7901425 | pubmed:dateCreated | 1993-12-13 | lld:pubmed |
| pubmed-article:7901425 | pubmed:abstractText | A comparative study of human CYP1A1 genotypes and enzymatic activity was performed in a racially diverse population in order to determine frequencies of CYP1A1 genetic polymorphisms and the relationship between CYP1A1 genotype and function. Restriction fragment length polymorphism analyses revealed significantly higher frequencies of a variant Msp1 polymorphism in Asians versus European-Americans, while African-American CYP1A1 genotypic frequencies more closely approximated those of Asians. Comparison of CYP1A1 genotypes at the Msp1 locus to a polymorphic site in exon 7 of the gene revealed a higher frequency of variant genotypes at the Msp1 site. Measurement of lymphocyte CYP1A1 enzyme activity by the ethoxyresorufin O-deethylase assay revealed significantly elevated levels of inducible enzyme activity among variant exon 7 genotypes when compared to wild-type genotypic individuals. These results demonstrate racially distinct patterns of CYP1A1 genotypes, and suggest a functional link between genotype and catalytic activity of the cytochrome P-450 protein responsible for the metabolism of many carcinogenic polycyclic aromatic hydrocarbons. | lld:pubmed |
| pubmed-article:7901425 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7901425 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7901425 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7901425 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7901425 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7901425 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7901425 | pubmed:issn | 0098-4108 | lld:pubmed |
| pubmed-article:7901425 | pubmed:author | pubmed-author:TaioliEE | lld:pubmed |
| pubmed-article:7901425 | pubmed:author | pubmed-author:TonioloPP | lld:pubmed |
| pubmed-article:7901425 | pubmed:author | pubmed-author:CosmaGG | lld:pubmed |
| pubmed-article:7901425 | pubmed:author | pubmed-author:GarteSS | lld:pubmed |
| pubmed-article:7901425 | pubmed:author | pubmed-author:CroftsFF | lld:pubmed |
| pubmed-article:7901425 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7901425 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:7901425 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7901425 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7901425 | pubmed:pagination | 309-16 | lld:pubmed |
| pubmed-article:7901425 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7901425 | pubmed:meshHeading | pubmed-meshheading:7901425-... | lld:pubmed |
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| pubmed-article:7901425 | pubmed:meshHeading | pubmed-meshheading:7901425-... | lld:pubmed |
| pubmed-article:7901425 | pubmed:articleTitle | Relationship between genotype and function of the human CYP1A1 gene. | lld:pubmed |
| pubmed-article:7901425 | pubmed:affiliation | Institute of Environmental Medicine, New York University Medical Center, New York 10987. | lld:pubmed |
| pubmed-article:7901425 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7901425 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7901425 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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