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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1995-4-21
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pubmed:abstractText |
We have studied the expression of the apoptosis-regulating genes bcl-2, bcl-x, bax and APO-1/fas (CD95) in human breast cancer. The expression pattern of these genes in human breast-cancer tissues and breast-cancer-derived cell lines was compared to that seen in normal breast epithelium and breast epithelial cell lines. No difference with regard to bcl-2 and bcl-xL expression was observed between normal breast epithelium and tumor tissue or breast cancer and non-malignant epithelial cell lines. In contrast, bax-alpha, a splice variant of bax, which promotes apoptosis, is expressed in high amounts in normal cell lines and breast tissue, whereas only weak or no expression could be detected in cancer-cell lines and malignant tissue. In contrast to malignant cell lines, which express low levels of bax-alpha, non-malignant epithelial cell lines displaying high amounts of bax-alpha were highly sensitive to induction of programmed cell death by both serum starvation and APO-1/fas (CD95) triggering. We therefore propose that dysregulation of apoptosis contributes to the pathogenesis of breast cancer, at least in part, due to an imbalance between anti-apoptosis genes (such as bcl-2/bcl-x) and apoptosis-promoting genes (bax).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BAX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0020-7136
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
60
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pubmed:geneSymbol |
bax-&agr;,
bcl-2,
bcl-x
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
854-9
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pubmed:dateRevised |
2007-7-24
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pubmed:meshHeading |
pubmed-meshheading:7896458-Apoptosis,
pubmed-meshheading:7896458-Base Sequence,
pubmed-meshheading:7896458-Breast Neoplasms,
pubmed-meshheading:7896458-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:7896458-Humans,
pubmed-meshheading:7896458-Molecular Sequence Data,
pubmed-meshheading:7896458-Proto-Oncogene Proteins,
pubmed-meshheading:7896458-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:7896458-RNA, Messenger,
pubmed-meshheading:7896458-Tumor Cells, Cultured,
pubmed-meshheading:7896458-bcl-2-Associated X Protein
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pubmed:year |
1995
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pubmed:articleTitle |
Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis.
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pubmed:affiliation |
Max Delbrück Center for Molecular Medicine, Berlin-Buch, Germany.
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pubmed:publicationType |
Journal Article
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