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rdf:type |
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lifeskim:mentions |
umls-concept:C0001657,
umls-concept:C0010124,
umls-concept:C0026160,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0044707,
umls-concept:C0243077,
umls-concept:C0441655,
umls-concept:C0597298,
umls-concept:C1414571,
umls-concept:C1706089
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pubmed:issue |
4
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pubmed:dateCreated |
1995-4-25
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pubmed:abstractText |
The effects of 11 alpha- and 11 beta-hydroxyprogesterone (11 alpha-OHP, 11 beta-OHP), on the activity of the glucocorticoid inactivating enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) were studied. 11 alpha-OHP and 11 beta-OHP were potent inhibitors of both 11 beta-HSD1 in rat liver microsomes and 11 beta-HSD2 in lysates of JEG-3 cells, a human choriocarcinoma cell line. In addition, both progesterone metabolites were markedly potent in conferring mineralocorticoid activity upon B in the adrenalectomized rat. These results provide insight into the structural properties required of inhibitors of 11 beta-HSD activity and indicate a possible role for endogenous 11 beta-HSD inhibitors in the regulation of glucocorticoid-induced Na+ retention.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0013-7227
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
136
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1809-12
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7895695-11-beta-Hydroxysteroid Dehydrogenases,
pubmed-meshheading:7895695-Adrenalectomy,
pubmed-meshheading:7895695-Animals,
pubmed-meshheading:7895695-Choriocarcinoma,
pubmed-meshheading:7895695-Corticosterone,
pubmed-meshheading:7895695-Humans,
pubmed-meshheading:7895695-Hydroxyprogesterones,
pubmed-meshheading:7895695-Hydroxysteroid Dehydrogenases,
pubmed-meshheading:7895695-Male,
pubmed-meshheading:7895695-Microsomes, Liver,
pubmed-meshheading:7895695-Natriuresis,
pubmed-meshheading:7895695-Potassium,
pubmed-meshheading:7895695-Rats,
pubmed-meshheading:7895695-Rats, Sprague-Dawley,
pubmed-meshheading:7895695-Tumor Cells, Cultured
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pubmed:year |
1995
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pubmed:articleTitle |
11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on corticosterone in the ADX rat.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Miriam Hospital, Providence, RI.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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