Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
|
pubmed:dateCreated |
1995-4-24
|
pubmed:abstractText |
Chronic food restriction produces a variety of physiological and behavioral adaptations including a potentiation of the reinforcing effect of food, drugs and lateral hypothalamic electrical stimulation. Previous work in this laboratory has revealed that the lowering of self-stimulation threshold by food restriction is reduced by mu- and kappa-selective opioid antagonists. In the present study, the effect of chronic food restriction on levels of three prodynorphin-derived peptides, namely dynorphin A1-17 (A1-17), dynorphin A1-8 (A1-8) and dynorphin B1-13 (B1-13) were measured in eleven brain regions known to be involved in appetite, taste and reward. Food restriction increased levels of A1-17 in dorsal medial (+19.6%), ventral medial (+24.2%) and medial preoptic (+82.9%) hypothalamic areas. Levels of A1-17 decreased in the central nucleus of the amygdala (-35.1%). Food restriction increased levels of A1-8 in nucleus accumbens (+34.4%), bed nucleus of the stria terminalis (+24.5%) and lateral hypothalamus (+41.9%). Food restriction had no effect on levels of B1-13. A1-17 is highly kappa-preferring and the brain regions in which levels increased all have a high ratio of kappa: mu and delta receptors. A1-8 is less discriminating among opioid receptor types and the brain regions in which levels increased have a low ratio of kappa: mu and delta receptors. The present results suggest that food restriction alters posttranslational processing within the dynorphin A domain of the prodynorphin precursor, possibly leading to a change in the balance between kappa and non-kappa opioid receptor stimulation in specific brain regions.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dynorphins,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalins,
http://linkedlifedata.com/resource/pubmed/chemical/Hypothalamic Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/dynorphin (1-8),
http://linkedlifedata.com/resource/pubmed/chemical/preproenkephalin
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0006-8993
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
21
|
pubmed:volume |
664
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
49-53
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:7895045-Animals,
pubmed-meshheading:7895045-Diet,
pubmed-meshheading:7895045-Dynorphins,
pubmed-meshheading:7895045-Enkephalins,
pubmed-meshheading:7895045-Hypothalamic Hormones,
pubmed-meshheading:7895045-Male,
pubmed-meshheading:7895045-Neuropeptides,
pubmed-meshheading:7895045-Peptide Fragments,
pubmed-meshheading:7895045-Protein Precursors,
pubmed-meshheading:7895045-Radioimmunoassay,
pubmed-meshheading:7895045-Rats,
pubmed-meshheading:7895045-Rats, Sprague-Dawley,
pubmed-meshheading:7895045-Time Factors
|
pubmed:year |
1994
|
pubmed:articleTitle |
Effects of chronic food restriction on prodynorphin-derived peptides in rat brain regions.
|
pubmed:affiliation |
Department of Psychiatry, New York University Medical Center, NY 10016.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|