Linked Life Data

7894265

Source:http://linkedlifedata.com/resource/pubmed/id/7894265

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-4-27
pubmed:abstractText
The dose-response curves for a number of alpha-adrenergic drugs were investigated to estimate a possible role of the alpha 2/alpha 1 selectivity of these drugs on the incidence of cortical high voltage spindles (HVS), reflecting level of vigilance. The alpha 2 antagonists yohimbine (0.25-4 mg/kg) and idazoxan (0.5-4 mg/kg), but not atipamezole induced a biphasic effect on the incidence of HVS in rats. This effect of relatively small doses of yohimbine and idazoxan should be taken into consideration when using these drugs as alpha 2 antagonists in behavioral and neurophysiological tests. On the other hand the linearity of the dose-response curve for atipamezole (0.01-4 mg/kg) indicates that this drug is a good candidate for use in such tests.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0924-977X
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
535-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Some unusual effects of alpha 2-adrenergic drugs on cortical high voltage spindles in rats.
pubmed:affiliation
Department of Neurology, University of Kuopio, Finland.
pubmed:publicationType
Journal Article