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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1995-4-27
|
| pubmed:abstractText |
The effects of the selective histamine H1-receptor agonist, 2-(3-trifluoromethylphenyl)histamine, were studied in rats implanted with electrodes for chronic sleep recordings. 2-(3-Trifluoromethylphenyl)histamine (80-120 micrograms) injected into the left lateral ventricle increased wakefulness, whereas slow wave sleep was reduced. Pretreatment with pyrilamine (2.0 mg/kg) prevented the effects of the H1-receptor agonist on wakefulness and slow wave sleep. Our results further support the involvement of histamine in the modulation of the waking state.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0924-977X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
459-62
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7894255-Animals,
pubmed-meshheading:7894255-Dose-Response Relationship, Drug,
pubmed-meshheading:7894255-Electrodes, Implanted,
pubmed-meshheading:7894255-Histamine,
pubmed-meshheading:7894255-Histamine Agonists,
pubmed-meshheading:7894255-Injections, Intraventricular,
pubmed-meshheading:7894255-Male,
pubmed-meshheading:7894255-Pyrilamine,
pubmed-meshheading:7894255-Rats,
pubmed-meshheading:7894255-Rats, Wistar,
pubmed-meshheading:7894255-Sleep,
pubmed-meshheading:7894255-Wakefulness
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
The selective histamine H1-receptor agonist 2-(3-trifluoromethylphenyl)histamine increases waking in the rat.
|
| pubmed:affiliation |
Department of Pharmacology and Therapeutics, School of Medicine, Clinics Hospital, Montevideo, Uruguay.
|
| pubmed:publicationType |
Journal Article
|