Linked Life Data

7894252

Source:http://linkedlifedata.com/resource/pubmed/id/7894252

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
1995-4-27
pubmed:abstractText
The cerebral cortex of rat's offspring was ultrastructurally examined after quinolinic acid administration to mothers during the gestation period. Quinolinic acid was administered intraperitoneally in a dose of 60 mmol, once daily, throughout the entire gestation period. Brain specimens were taken on day 5 after birth, from experimental and control animals. Ultrastructural analysis of the cortex tissue revealed maturing neuronal cell bodies and immaturelike cells. The distinguishing feature of altered maturing neuronal cell bodies was the presence of vacuoles and/or swollen cytoplasm. The vacuoles were present in the perikaryon as well as in the processes. As a rule, the organelles within swollen cytoplasm were scarce, and the cytoplasm itself had a distinctly lower electron density. In some cases a loss of chromatin grains was noted. The nuclear envelope was distended, forming perinuclearly situated channels and vacuoles. The most frequently observed change in the immature-like cells was a marked swelling of the cytoplasm, hence only few organelles could be seen. Only few synaptic complexes were present and their contact was weakly marked. The axon endings contained sometimes few vesicles. The postsynaptic dendritic processes were frequently significantly swollen. Astrocytes were swollen.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0940-2993
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
397-402
pubmed:dateRevised
2006-10-30
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Toxic effect of quinolinic acid administered during pregnancy on the cerebral cortex of rat's offspring: an ultrastructural study.
pubmed:affiliation
Medical Centre of Postgraduate Education, Laboratory of Histochemistry, Warsaw, Poland.
pubmed:publicationType
Journal Article