Linked Life Data

7893592

Source:http://linkedlifedata.com/resource/pubmed/id/7893592

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-4-25
pubmed:abstractText
Few data are available on the reliability of measurements of adrenocortical and corticotroph hormones for use in clinical pharmacology. Two placebo controlled cross-over trials in 20 normal healthy male subjects offered the opportunity to perform three repeat samplings of adrenocortical and corticotroph hormones at 1 to 5 week intervals during the placebo periods. Measurements of baseline levels of plasma, salivary and urinary cortisol, plasma adrenocorticotroph hormone (ACTH), lipotrophic hormone (LPH), beta-endorphin, post tetracosactrin levels of plasma and salivary cortisol, post corticotrophin releasing hormone (CRH)-lysine vasopressine (LVP) levels of plasma cortisol, ACTH and LPH; and post metyrapone levels of plasma cortisol and 11-deoxycortisol (compound S), ACTH, LPH, beta-endorphin were performed in the same laboratory. The reliability of the measurements was estimated by computing the intraclass correlation coefficient (R) and by using Altman-Bland graphical method. The Rs of baseline parameters varied from 0.18 (for 08.00 h salivary cortisol) to 0.55 (for 08.00 h plasma cortisol and nocturnal urinary cortisol). In contrast, parameters obtained after direct stimulation or inhibition of the producing targets were much more reliable: Rs were above 0.80 for post tetracosactrin levels of plasma and salivary cortisol, post CRH-LVP levels of plasma ACTH and LPH. The Rs were below 0.50 for post metyrapone levels of plasma 11-deoxycortisol, ACTH, LPH and beta-endorphin. The interval between sampling did not affect R estimates. These data show that peak levels of plasma cortisol and ACTH after direct stimulation are highly reliable whereas baseline and main post-metyrapone levels are not.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0306-5251
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
474-9
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:7893592-Adrenocorticotropic Hormone, pubmed-meshheading:7893592-Adult, pubmed-meshheading:7893592-Corticotropin-Releasing Hormone, pubmed-meshheading:7893592-Cortodoxone, pubmed-meshheading:7893592-Cross-Over Studies, pubmed-meshheading:7893592-Double-Blind Method, pubmed-meshheading:7893592-Hormones, pubmed-meshheading:7893592-Humans, pubmed-meshheading:7893592-Hydrocortisone, pubmed-meshheading:7893592-Hypothalamo-Hypophyseal System, pubmed-meshheading:7893592-Immunoradiometric Assay, pubmed-meshheading:7893592-Lypressin, pubmed-meshheading:7893592-Male, pubmed-meshheading:7893592-Pituitary-Adrenal System, pubmed-meshheading:7893592-Reproducibility of Results, pubmed-meshheading:7893592-Saliva, pubmed-meshheading:7893592-beta-Endorphin, pubmed-meshheading:7893592-beta-Lipotropin
pubmed:year
1994
pubmed:articleTitle
Reliability of hormonal levels for assessing the hypothalamic-pituitary-adrenocortical system in clinical pharmacology.
pubmed:affiliation
Département de Biostatistique et d'Informatique Médicale, Hôpital Cochin, Paris, France.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial