Linked Life Data

7893172

Source:http://linkedlifedata.com/resource/pubmed/id/7893172

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-4-20
pubmed:abstractText
Proguanil, an orally administered antimalarial drug, was given to 36 individuals (200 mg daily for 3 days). The antimalarial activity in plasma samples collected after the drug administration was then determined by bioassay. Concentrations of proguanil and cycloguanil (the principal active metabolite) in these samples were also measured by high performance liquid chromatography. A regression analysis was then performed on these variables to determine if the antimalarial activity of the samples was due to proguanil alone or to proguanil and cycloguanil together. The analysis indicated that cycloguanil is the main determinant of antimalarial activity after proguanil administration and that the activity of cycloguanil is not influenced by the presence of proguanil.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0003-4983
pubmed:author
pubmed:issnType
Print
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
587-94
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
A statistical analysis of the antimalarial activity of proguanil and cycloguanil in human volunteers.
pubmed:affiliation
Army Malaria Research Unit, University of Sydney, Liverpool Military Area, New South Wales, Australia.
pubmed:publicationType
Journal Article