Linked Life Data

7892429

Source:http://linkedlifedata.com/resource/pubmed/id/7892429

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-4-20
pubmed:abstractText
Two groups of rats received chronic ethanol treatment in quiet or noisy housing conditions. Animals from both housing conditions were then withdrawn from ethanol for 12 h prior to testing in the social interaction and elevated plus-maze tests of anxiety. Both ethanol withdrawal groups showed marked hypoactivity (decreased motor activity and decreased closed arm entries in the plus-maze), but they differed in their anxiogenic response (decreased social interaction and percentage of time spent on the open arms), with only the group treated in quiet conditions showing a significant response. A similar pattern of results was found in rats tested 18 h after withdrawal and thus it is unlikely that the anxiogenic response was simply delayed in time. It therefore seemed that chronic exposure to noise during the chronic ethanol treatment modifies dependence, but only as assessed by measures reflecting anxiety. This implies that the adaptive changes are suppressed only in the neural pathways mediating anxiety; possible mediating factors are discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0033-3158
pubmed:author
pubmed:issnType
Print
pubmed:volume
116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
369-72
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Chronic exposure to noise modifies the anxiogenic response, but not the hypoactivity, detected on withdrawal from chronic ethanol treatment.
pubmed:affiliation
Psychopharmacology Research Unit, UMDS Division of Pharmacology, Guy's Hospital, London, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't