Linked Life Data

7892241

Source:http://linkedlifedata.com/resource/pubmed/id/7892241

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-4-20
pubmed:abstractText
The structure and materials of the blood vessel wall are layered. This article presents the principle of a method to determine the mechanical properties of the different layers in vivo. In vivo measurement begets in vivo data and avoids pitfalls of in vitro tests of dissected specimens. With the proposed method, we can measure vessels of diameters 100 microns and up and obtain data on vascular smooth muscles and adventitia. To derive the full constitutive equations, one must first determine the zero-stress state, obtain the morphometric data on the thicknesses of the layers, and make mechanical measurements in the neighborhood of the zero-stress state. Then eight small perturbation experiments are done on earth blood vessel in vivo to determine eight incremental elastic moduli of the two layers of the blood vessel wall. The calculation requires the morphometric data and the location of the neutral axis. The experiments are simple, the interpretation is definitive, but the analysis is somewhat sophisticated. The method will yield results that are needed to assess the stress and strain in the tissues of the blood vessel. The subject is important because blood vessels remodel themselves significantly and rapidly when their stress and strain deviate from their homeostatic values, and because cell proliferation, differentiation, adhesion, contraction, and locomotion depend on stress and strain in the tissue.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892241-1539714, http://linkedlifedata.com/resource/pubmed/commentcorrection/7892241-1733801, http://linkedlifedata.com/resource/pubmed/commentcorrection/7892241-1928868, http://linkedlifedata.com/resource/pubmed/commentcorrection/7892241-495769, http://linkedlifedata.com/resource/pubmed/commentcorrection/7892241-5661939, http://linkedlifedata.com/resource/pubmed/commentcorrection/7892241-6520132, http://linkedlifedata.com/resource/pubmed/commentcorrection/7892241-6715386, http://linkedlifedata.com/resource/pubmed/commentcorrection/7892241-8302025, http://linkedlifedata.com/resource/pubmed/commentcorrection/7892241-8302029, http://linkedlifedata.com/resource/pubmed/commentcorrection/7892241-8342664, http://linkedlifedata.com/resource/pubmed/commentcorrection/7892241-8368648
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2169-73
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Determination of the mechanical properties of the different layers of blood vessels in vivo.
pubmed:affiliation
Department of Bioengineering, University of California, San Diego, La Jolla 92093-0412.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.