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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1995-4-20
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pubmed:databankReference |
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pubmed:abstractText |
Sporulation of Bacillus subtilis requires the coordinated expression of two separate developmental programs in the mother cell and forespore compartments by sigma E and sigma F, respectively. This coordination is maintained through the action of cross-regulatory factors that control the activities of the various sporulation-specific sigma factors. We present here the isolation and characterization of one such cross-regulatory factor, the spoIIR gene. Using a genetic screen, we have isolated four mutant alleles of spoIIR. These mutants were isolated as expressing sigma F-directed genes but not sigma E-directed genes. The block in sigma E-directed gene expression in spoIIR mutants was caused by an inability to process pro-sigma E to its active form. Cloning and characterization of the spoIIR gene determined that its transcription is directed by sigma F. Thus, SpoIIR is required for linking the activation of sigma E to the activation of sigma F and coordinating the initiation of the two developmental programs required to form a spore.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-1538747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-1551857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-1744043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-1900494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-1942049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-1943780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-1946462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-1948031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-2105300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-2106508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-2123551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-2174858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-2497051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-2500645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-2504702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-3029030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-3125985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-3918005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-4976945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-7961438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-8113187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-8168129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-8188591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-8327482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-8355618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-8449878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7892217-8464402
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
92
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pubmed:geneSymbol |
spoIIAC(P),
spoIIAC561,
spoIIAC563,
spoIIR
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2012-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7892217-Amino Acid Sequence,
pubmed-meshheading:7892217-Bacillus subtilis,
pubmed-meshheading:7892217-Bacterial Proteins,
pubmed-meshheading:7892217-Base Sequence,
pubmed-meshheading:7892217-Blotting, Southern,
pubmed-meshheading:7892217-Blotting, Western,
pubmed-meshheading:7892217-Chromosomes, Artificial, Yeast,
pubmed-meshheading:7892217-Consensus Sequence,
pubmed-meshheading:7892217-Genes, Bacterial,
pubmed-meshheading:7892217-Kinetics,
pubmed-meshheading:7892217-Molecular Sequence Data,
pubmed-meshheading:7892217-Mutagenesis,
pubmed-meshheading:7892217-Open Reading Frames,
pubmed-meshheading:7892217-Promoter Regions, Genetic,
pubmed-meshheading:7892217-Restriction Mapping,
pubmed-meshheading:7892217-Sigma Factor,
pubmed-meshheading:7892217-Spores, Bacterial,
pubmed-meshheading:7892217-Transcription, Genetic,
pubmed-meshheading:7892217-Transcription Factors
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pubmed:year |
1995
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pubmed:articleTitle |
Identification of a gene, spoIIR, that links the activation of sigma E to the transcriptional activity of sigma F during sporulation in Bacillus subtilis.
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pubmed:affiliation |
Department of Microbiology and Immunology, Temple University Medical School, Philadelphia, PA 19140.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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