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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1995-4-20
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pubmed:abstractText |
Aggregative adhesion of Klebsiella pneumoniae LM3 to Intestine-407 (Int-407) cells was studied. Adhesive capacities were affected by the bacterial growth phase (with a maximum of adherence obtained during the exponential phase), temperature, multiplicity of infection, and length of incubation with Int-407 cells. Adhesion occurred through a cytochalasin D-sensitive process and was greatly reduced after treatment of Int-407 with cycloheximide, indicating that aggregative adhesion requires active participation of Int-407 cells. Transmission electron microscopy revealed that adherent bacteria were surrounded by a capsule-like material, apparently involved in both bacterium-Int-407 cell and bacterium-bacterium adherence. Examination with a scanning electron microscope showed interactions of intestinal cell microvilli with bacteria and formation in 3 h of a fibrous network within and around the bacterial clusters. We speculate that aggregative adhesion of K. pneumoniae mediated by a capsule-like extracellular material might explain the persistence of these strains inside the host gastrointestinal tract.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-1345909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-1348724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-1358987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-1398907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-1416900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-1587620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-1680107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-1995723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-2349239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-2563383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-2592552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-2647635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-2859247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-2899125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-3049556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-3055177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-3292660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-3313248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-3512838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-3514461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-3543152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-6146569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-6187694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-6249871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-6352891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-8005680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-8225577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-8406879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-8406885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-8423076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-8432608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7890389-8514418
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1318-28
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7890389-Bacterial Adhesion,
pubmed-meshheading:7890389-Bacterial Capsules,
pubmed-meshheading:7890389-Cells, Cultured,
pubmed-meshheading:7890389-Cycloheximide,
pubmed-meshheading:7890389-Cytochalasin D,
pubmed-meshheading:7890389-Humans,
pubmed-meshheading:7890389-Intestines,
pubmed-meshheading:7890389-Klebsiella pneumoniae,
pubmed-meshheading:7890389-Microscopy, Electron,
pubmed-meshheading:7890389-Microscopy, Electron, Scanning,
pubmed-meshheading:7890389-Temperature
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pubmed:year |
1995
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pubmed:articleTitle |
Aggregative adherence of Klebsiella pneumoniae to human intestine-407 cells.
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pubmed:affiliation |
Laboratoire de Bactériologie, Faculté de Pharmacie, Clermont-Ferrand, France.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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