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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-4-20
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pubmed:abstractText |
To determine the potential roles of c-jun in lymphocyte development, we generated somatic chimeric mice by injecting homozygous c-jun mutant embryonic stem (ES) cells into blastocysts from recombination activating gene-2 (RAG-2)-deficient mice. Chimeric mice had poor restoration of thymocytes, but contained substantial numbers of mature T and B lymphocytes in the periphery. Stimulation of c-jun-/- B cells resulted in normal levels of proliferation and immunoglobulin secretion. Likewise, stimulation of c-jun-/- T cells resulted in essentially normal levels of IL-2R alpha expression, IL-2 secretion, and proliferation. We further showed that the relatively normal activation responses of the c-jun-/- T cells probably results from the fact that other members of the Jun family contribute to the bulk of the activator protein-1 (AP-1) complexes in normal T cells and, as a result, AP-1 complexes are found at relatively normal levels in c-jun-/- T cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:geneSymbol |
c-jun
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
65-72
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7889400-Animals,
pubmed-meshheading:7889400-B-Lymphocytes,
pubmed-meshheading:7889400-Base Sequence,
pubmed-meshheading:7889400-Cell Differentiation,
pubmed-meshheading:7889400-Chimera,
pubmed-meshheading:7889400-Genes, jun,
pubmed-meshheading:7889400-Hematopoietic Stem Cells,
pubmed-meshheading:7889400-Homozygote,
pubmed-meshheading:7889400-Interleukin-2,
pubmed-meshheading:7889400-Lymphocyte Activation,
pubmed-meshheading:7889400-Mice,
pubmed-meshheading:7889400-Molecular Sequence Data,
pubmed-meshheading:7889400-Mutation,
pubmed-meshheading:7889400-Oligodeoxyribonucleotides,
pubmed-meshheading:7889400-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:7889400-T-Lymphocytes,
pubmed-meshheading:7889400-Transcription Factor AP-1,
pubmed-meshheading:7889400-Transcription Factors
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pubmed:year |
1994
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pubmed:articleTitle |
Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells.
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pubmed:affiliation |
Howard Hughes Medical Institute, Children's Hospital, Department of Genetics, Boston, Massachusetts.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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