| pubmed-article:7889302 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7889302 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:7889302 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7889302 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:7889302 | lifeskim:mentions | umls-concept:C0227651 | lld:lifeskim |
| pubmed-article:7889302 | lifeskim:mentions | umls-concept:C0001480 | lld:lifeskim |
| pubmed-article:7889302 | lifeskim:mentions | umls-concept:C0042010 | lld:lifeskim |
| pubmed-article:7889302 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:7889302 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:7889302 | lifeskim:mentions | umls-concept:C1155502 | lld:lifeskim |
| pubmed-article:7889302 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:7889302 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7889302 | pubmed:dateCreated | 1995-4-19 | lld:pubmed |
| pubmed-article:7889302 | pubmed:abstractText | 1. Extracellular ATP and UTP have been reported to activate a nucleotide receptor that mediates phosphoinositide and phosphatidylcholine hydrolysis by phospholipases C and D, respectively. Here we report that ATP and UTP potently stimulate mesangial cell proliferation. 2. Both nucleotides stimulate phosphorylation and activation of mitogen-activated protein kinase and a biphasic phosphorylation of the up-stream mitogen-activated protein kinase kinase. 3. When added at 100 microM, ATP gamma S, UTP and ATP were the most potent activators of mitogen-activated protein kinase. beta gamma-imido-ATP was somewhat less active and ADP and 2-methylthio-ATP caused a weak induction of enzyme activity. Activation of mitogen-activated protein kinase by both ATP and UTP is dose-dependently attenuated by the P2-receptor antagonist, suramin. 4. The protein kinase C activator 12-0-tetradecanoylphorbol 13-acetate, but not the biologically inactive 4 alpha-phorbol 12,13-didecanoate, increased mitogen-activated protein kinase activity in mesangial cells, suggesting that protein kinase C may mediate nucleotide-induced stimulation of mitogen-activated protein kinase. 5. Down-regulation of protein kinase C -alpha and -delta isoenzymes by 4 h or 8 h treatment with phorbol ester partially inhibited ATP- and UTP-triggered mitogen-activated protein kinase activation. Moreover, a 24 h treatment of mesangial cells with phorbol ester, a regimen that also causes depletion of protein kinase C-epsilon did not further reduce the level of mitogen-activated protein kinase stimulation. 6. The specific protein kinase C inhibitor, CGP 41251, which displayed a selectivity for the Ca2+-dependent isoenzymes, as compared to the Ca2+-independent isoenzymes did not inhibit nucleotide stimulated mitogen-activated protein kinase phosphorylation, thus implicating the involvement of a Ca2+-independent protein kinase C isoform.7. In summary, these results suggest that ATP and UTP trigger the activation of the mitogen-activated protein kinase signalling cascade in mesangial cells and this may be responsible for the potent mitogenic activity of both nucleotides. | lld:pubmed |
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| pubmed-article:7889302 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7889302 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889302 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7889302 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7889302 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7889302 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:7889302 | pubmed:author | pubmed-author:Pfeilschifter... | lld:pubmed |
| pubmed-article:7889302 | pubmed:author | pubmed-author:HuwilerAA | lld:pubmed |
| pubmed-article:7889302 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7889302 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:7889302 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7889302 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7889302 | pubmed:pagination | 1455-63 | lld:pubmed |
| pubmed-article:7889302 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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