Linked Life Data

7888580

Source:http://linkedlifedata.com/resource/pubmed/id/7888580

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1995-4-17
pubmed:abstractText
There is extensive experimental and surgical experience with the use of bone tissue to fill defects in the skeleton, to bridge non-union sites, and to pack defects in bone created from cyst curettage. DP-bioactive glass with a chemical composition of Na2O 8.4%, SiO2 39.6%, P2O5 12% and CaO 40% has been reported as an alternative bone substitute of high mechanical strength, good biocompatibility. and which has a tight bond with living tissue. The bonding layer between DP-bioactive glass and bone tissue was considered to be formed by dissolution of calcium and phosphate ions from the DP-bioactive glass into the surrounding body fluids. The biological hydroxyapatite was suspected to deposit directly onto the bonding layer. In order to confirm the interaction between the DP-bioactive glass and bone tissue, the developed bioactive glass was implanted into rabbit femur condyle for 2-32 weeks. The histological evaluation of DP-bioactive glass as a bone substitute was also investigated in the study. Porous hydroxyapatite bioceramic was used in the control group and the results were compared with those of DP-bioactive glass. The interface between the DP-bioactive glass and bone tissue examined with SEM-EPMA showed that the bioactive glass formed a reaction layer on the surface within 2 weeks after operation and formed a direct bond with natural bone. The elements contained in the bioactive glass apparently interdiffuse with the living bone and biological hydroxyapatite deposited onto the diffusion area, which was proved by EPMA and TEM. After implantation for over 8 weeks, the DP-bioactive glass was gradually biodegraded and absorbed by the living bone. Histological examination using the optical microscope showed that osteocytes grow into the inside of the DP-bioactive glass and the bioactive glass would be expected to be a part of bone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0142-9612
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1087-98
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7888580-Animals, pubmed-meshheading:7888580-Biomechanics, pubmed-meshheading:7888580-Body Fluids, pubmed-meshheading:7888580-Bone Regeneration, pubmed-meshheading:7888580-Bone Substitutes, pubmed-meshheading:7888580-Calcium Compounds, pubmed-meshheading:7888580-Diffusion, pubmed-meshheading:7888580-Electron Probe Microanalysis, pubmed-meshheading:7888580-Femur, pubmed-meshheading:7888580-Glass, pubmed-meshheading:7888580-Hydroxyapatites, pubmed-meshheading:7888580-Male, pubmed-meshheading:7888580-Microscopy, Electron, pubmed-meshheading:7888580-Microscopy, Electron, Scanning, pubmed-meshheading:7888580-Nitrogen Oxides, pubmed-meshheading:7888580-Oxides, pubmed-meshheading:7888580-Phosphorus, pubmed-meshheading:7888580-Prostheses and Implants, pubmed-meshheading:7888580-Rabbits, pubmed-meshheading:7888580-Silicon Dioxide, pubmed-meshheading:7888580-Temperature, pubmed-meshheading:7888580-X-Ray Diffraction
pubmed:year
1994
pubmed:articleTitle
Sintered porous DP-bioactive glass and hydroxyapatite as bone substitute.
pubmed:affiliation
Center for Biomedical Engineering, College of Medicine, National Taiwan University, Taipei, Republic of China.
pubmed:publicationType
Journal Article, Comparative Study