Linked Life Data

7887957

Source:http://linkedlifedata.com/resource/pubmed/id/7887957

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-4-13
pubmed:abstractText
We report here for the first time a 20-kDa hamster lacrimal gland major protein whose expression is markedly inhibited by physiological levels of both androgens and estrogens. This novel protein was present in adult females but not in males. In females, its level was several fold elevated on ovariectomy to apparently 20% of total soluble proteins. Castration in males induced this 20-kDa protein from undetectable to ovariectomized female levels. Administration of only androgens or estrogens to gonadectomized hamsters of both sexes obliterated this major lacrimal protein and estrogens were more potent than androgens. The 20-kDa lacrimal protein was secreted only in female tears. This lacrimal 20-kDa protein of yet unknown function is a useful marker to study the hormonal regulation of the lacrimal gland and it provides a model system to study how both androgens and estrogens mediate inhibition of a specific protein's expression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
208
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
412-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Androgens and estrogens markedly inhibit expression of a 20-kDa major protein in hamster exorbital lacrimal gland.
pubmed:affiliation
Centre for Cellular & Molecular Biology, Hyderabad, India.
pubmed:publicationType
Journal Article, Comparative Study