|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1995-4-13
|
|
pubmed:abstractText |
Interleukin 3 is a cytokine that stimulates proliferation and differentiation of hematopoietic progenitor cells. Its receptor consists of two subunits, an interleukin 3-specific alpha subunit and a beta subunit shared by garanulocyte-macrophage colony stimulating factor and interleukin 5 receptors. In this paper, we determined the genomic structure of the alpha subunit of the human interleukin 3 receptor, which spans approximately 40 kb and has 12 exons. We found that the genomic structures of the alpha subunits of the human interleukin 3 and granulocyte-macrophage colony stimulating factor receptors are very similar. They possess a unique additional intron in the 'C domain', which is absent in the alpha subunit of the interleukin 5 receptor. These results suggest a shared evolutionary pathway of these two genes.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-5,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
8
|
|
pubmed:volume |
208
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
360-7
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:7887951-Base Sequence,
pubmed-meshheading:7887951-Biological Evolution,
pubmed-meshheading:7887951-Blotting, Southern,
pubmed-meshheading:7887951-Cloning, Molecular,
pubmed-meshheading:7887951-Conserved Sequence,
pubmed-meshheading:7887951-DNA Primers,
pubmed-meshheading:7887951-Exons,
pubmed-meshheading:7887951-Humans,
pubmed-meshheading:7887951-Introns,
pubmed-meshheading:7887951-Macromolecular Substances,
pubmed-meshheading:7887951-Molecular Sequence Data,
pubmed-meshheading:7887951-Polymerase Chain Reaction,
pubmed-meshheading:7887951-Receptors, Cytokine,
pubmed-meshheading:7887951-Receptors, Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:7887951-Receptors, Interleukin,
pubmed-meshheading:7887951-Receptors, Interleukin-3,
pubmed-meshheading:7887951-Receptors, Interleukin-5,
pubmed-meshheading:7887951-Recombinant Proteins,
pubmed-meshheading:7887951-Restriction Mapping,
pubmed-meshheading:7887951-Sequence Homology, Nucleic Acid
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
Structure of the gene encoding the alpha subunit of the human interleukin 3 receptor.
|
|
pubmed:affiliation |
Department of Molecular and Developmental Biology, University of Tokyo, Japan.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
