Linked Life Data

7886072

Source:http://linkedlifedata.com/resource/pubmed/id/7886072

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-4-12
pubmed:abstractText
The present experiments investigated the effects of route of drug injection on two of the phenomena associated with repeated, cued, morphine administration. Experiment 1 examined the degree of situational specificity of analgesic tolerance following 5 days of morphine (5 mg/kg) delivered either subcutaneously (SC) or intravenously (i.v.). Situationally specific tolerance was only observed following i.v. morphine, although nonspecific tolerance was evident in both instances. Experiment 2 indicated that this difference was not due to dose, as neither 2.5 or 7.5 mg/kg SC morphine produced demonstrable situationally specific tolerance. Experiment 3 examined the putative existence of compensatory responses underlying the observed tolerance. Hyperalgesia in response to the environment in which morphine was experienced was evident in animals trained with i.v. morphine, but not in those receiving repeated SC injections. Potential explanations for these effects of route of administration are discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1029-35
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Route of morphine administration modulates conditioned analgesic tolerance and hyperalgesia.
pubmed:affiliation
Department of Psychology-Behavioral Neurosciences, University of Colorado, Boulder 80309.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.