Linked Life Data

7886028

Source:http://linkedlifedata.com/resource/pubmed/id/7886028

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1995-4-13
pubmed:abstractText
Selenite and cadmium both cause reproductive effects in animals. Cadmium is an acute placental toxicant, with apparent limited transfer to the fetus. This study examines the placental transfer of selenite, and the hypothesis that similar to cadmium, selenite may also be a direct placental toxicant. Using dual perfusion of the human term placental lobule, both non-protein bound (< 776 Da) selenite and cadmium equilibrated across the placenta within 4 h. The transfer of selenium, added as selenite, was not limited at concentrations from 2-40 nmol/ml. At initial maternal concentrations of 20 nmol/ml, selenium attained higher concentrations in the fetal perfusate compared with cadmium concentrations. Protein binding of cadmium in perfusates (45 per cent at 30 min) and placental cytosol (approx. 87 per cent) was greater than selenium (perfusate, 7 per cent at 30 min, cytosol, 50-60 per cent), which may partially account for the differences in placental transfer. Cadmium (20 nmol/ml) produced adverse effects on the production and release of human chorionic gonadotropin (hCG) in 4 h. No adverse effects were noted during 4 h exposures to selenite at initial concentrations of up to 40 nmol/ml. Thus, unlike cadmium, in which placental accumulation and direct placental toxicity contributed to acute reproductive effects, selenite at concentrations up to 40 nmol/ml was not a direct toxicant under these perfusion conditions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0143-4004
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
883-95
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
The placental transfer and toxicity of selenite relative to cadmium in the human term perfused placenta.
pubmed:affiliation
Department of Obstetrics and Gynecology, University of Rochester Medical Center, New York 14642-8668.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, U.S. Gov't, P.H.S.