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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1995-4-10
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pubmed:abstractText |
The role of innate, alpha/beta interferon (IFN-alpha/beta)-dependent protection versus specific antibody-mediated protection against vesicular stomatitis virus (VSV) was evaluated in IFN-alpha/beta receptor-deficient mice (IFN-alpha/beta R0/0 mice). VSV is a close relative to rabies virus that causes neurological disease in mice. In contrast to normal mice, IFN-alpha/beta R0/0 mice were highly susceptible to infection with VSV because of ubiquitous high viral replication. Adoptive transfer experiments showed that neutralizing antibodies against the glycoprotein of VSV (VSV-G) protected these mice efficiently against systemic infection and against peripheral subcutaneous infection but protected only to a limited degree against intranasal infection with VSV. In contrast, VSV-specific T cells or antibodies specific for the nucleoprotein of VSV (VSV-N) were unable to protect IFN-alpha/beta R0/0 mice against VSV. These results demonstrate that mice are extremely sensitive to VSV if IFN-alpha/beta is not functional and that under these conditions, neutralizing antibody responses mediate efficient protection, but apparently only against extraneuronal infection.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-13641571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-1658936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-1673361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-186554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-1899893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-2000406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-2021425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-2033678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-2435794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-2849570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-2981435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-3546579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-4118869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-4190338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-4336813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-6095272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-6154097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-6180550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-6328040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-7684471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-7935164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-8009221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-8105106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-8173982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-8371354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-8381052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7884863-8389912
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/G protein, vesicular stomatitis...,
http://linkedlifedata.com/resource/pubmed/chemical/Immune Sera,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Interferon alpha-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interferon,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Envelope Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2153-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7884863-Animals,
pubmed-meshheading:7884863-Antibodies, Viral,
pubmed-meshheading:7884863-Cell Line,
pubmed-meshheading:7884863-Cercopithecus aethiops,
pubmed-meshheading:7884863-Cricetinae,
pubmed-meshheading:7884863-Immune Sera,
pubmed-meshheading:7884863-Immunotherapy, Adoptive,
pubmed-meshheading:7884863-Membrane Glycoproteins,
pubmed-meshheading:7884863-Membrane Proteins,
pubmed-meshheading:7884863-Mice,
pubmed-meshheading:7884863-Neutralization Tests,
pubmed-meshheading:7884863-Receptor, Interferon alpha-beta,
pubmed-meshheading:7884863-Receptors, Interferon,
pubmed-meshheading:7884863-Rhabdoviridae Infections,
pubmed-meshheading:7884863-Vero Cells,
pubmed-meshheading:7884863-Vesicular stomatitis Indiana virus,
pubmed-meshheading:7884863-Viral Envelope Proteins,
pubmed-meshheading:7884863-Virus Replication
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pubmed:year |
1995
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pubmed:articleTitle |
Antiviral protection by vesicular stomatitis virus-specific antibodies in alpha/beta interferon receptor-deficient mice.
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pubmed:affiliation |
Department of Pathology, University of Zürich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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