Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1995-4-12
pubmed:abstractText
This review will focus on the role of sphingosine and its phosphorylated derivative sphingosine-1-phosphate (SPP) in cell growth regulation and signal transduction. We will show that many of the effects attributed to sphingosine in quiescent Swiss 3T3 fibroblasts are mediated via its conversion to SPP. We propose that SPP has appropriate properties to function as an intracellular second messenger based on the following: it elicits diverse cellular responses; it is rapidly produced from sphingosine by a specific kinase and rapidly degraded by a specific lyase; its concentration is low in quiescent cells but increases rapidly and transiently in response to the growth factors, fetal calf serum (FCS) and platelet derived growth factor (PDGF); it releases Ca2+ from internal sources in an InsP3-independent manner; and finally, it may link sphingolipid signaling pathways to cellular ras-mediated signaling pathways by elevating phosphatidic acid levels. The effects of this novel second messenger on growth, differentiation and invasion of human breast cancer cells will be discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0167-6806
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
337-48
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:7881110-3T3 Cells, pubmed-meshheading:7881110-Animals, pubmed-meshheading:7881110-Blood Physiological Phenomena, pubmed-meshheading:7881110-Breast Neoplasms, pubmed-meshheading:7881110-Calcium, pubmed-meshheading:7881110-Cattle, pubmed-meshheading:7881110-Cell Division, pubmed-meshheading:7881110-Cell Movement, pubmed-meshheading:7881110-Growth Substances, pubmed-meshheading:7881110-Humans, pubmed-meshheading:7881110-Lysophospholipids, pubmed-meshheading:7881110-Mice, pubmed-meshheading:7881110-Models, Biological, pubmed-meshheading:7881110-Neoplasm Invasiveness, pubmed-meshheading:7881110-Phosphatidic Acids, pubmed-meshheading:7881110-Platelet-Derived Growth Factor, pubmed-meshheading:7881110-Second Messenger Systems, pubmed-meshheading:7881110-Signal Transduction, pubmed-meshheading:7881110-Sphingosine, pubmed-meshheading:7881110-Tumor Cells, Cultured
pubmed:year
1994
pubmed:articleTitle
Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells.
pubmed:affiliation
Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't