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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-4-12
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pubmed:abstractText |
The expression and prognostic significance of the c-erbB-2 oncogene product was studied in 55 cases of childhood medulloblastoma. Forty-six of the 55 tumours (83.6%) expressed the c-erbB-2 product. The percentage of tumour cells expressing the c-erbB-2 product proved to be a significant indicator of patient outcome when analysed as both a categorical and a continuous variable. As a categorical variable, patients with more than 50% positive tumour cells had a significantly worse survival, with only 10% alive at 10 years vs 48% for those with less than 50% positive tumour cells (log rank P = 0.0049). To demonstrate that this observed prognostic significance was both independent and not a result of 'data-driven' categorisation, it was also entered into the Cox model as a continuous variable. Prognostic significance was retained in P = 0.038.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-1346155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-1361526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-1672253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-1672254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-1672256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-1672668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-1968437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-1973458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-1979253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-2141512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-2188097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-2394606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-2430175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-2470152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-2566907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-2572267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-2573579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-2870269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-2893663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-2899890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-3301694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-3317411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-3334992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-3422050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-3435712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-3783262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-4793138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-6095109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-6166661,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-7241214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7880726-8478656
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:geneSymbol |
c-erbB-2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
473-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7880726-Adolescent,
pubmed-meshheading:7880726-Cerebellar Neoplasms,
pubmed-meshheading:7880726-Child,
pubmed-meshheading:7880726-Child, Preschool,
pubmed-meshheading:7880726-Chromosomes, Human, Pair 17,
pubmed-meshheading:7880726-Cytoplasm,
pubmed-meshheading:7880726-Female,
pubmed-meshheading:7880726-Humans,
pubmed-meshheading:7880726-Infant,
pubmed-meshheading:7880726-Infant, Newborn,
pubmed-meshheading:7880726-Male,
pubmed-meshheading:7880726-Medulloblastoma,
pubmed-meshheading:7880726-Predictive Value of Tests,
pubmed-meshheading:7880726-Prognosis,
pubmed-meshheading:7880726-Receptor, erbB-2
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pubmed:year |
1995
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pubmed:articleTitle |
Prognostic significance of the c-erbB-2 oncogene product in childhood medulloblastoma.
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pubmed:affiliation |
Department of Child Health, University of Newcastle Upon Tyne Medical School, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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