Linked Life Data

7879436

Source:http://linkedlifedata.com/resource/pubmed/id/7879436

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-4-6
pubmed:abstractText
Amphetamine (1 mg/kg) increased the rate of pedal self-stimulation of the lateral hypothalamus of Wistar rats in Skinner box by 37%. Lesion of the medial prefrontal cortex with kainic acid (16 mcg/kg in 8 mcl) 10-14 days prior to the experiment did not prevent facilitating effect of amphetamine on self-stimulation. Lysergic acid diethylamid (10 mcg/kg) did not influence self-stimulation response in rats with damaged medial prefrontal cortex, but after its preliminary administration prevented the stimulating effect of amphetamine on self-stimulation of the lateral hypothalamus. The findings are discussed from two points of view: 1) the phenomenon observed is associated with the existence of hypothalamic autoregulatory dopaminergic system which provides realization of self-stimulation; 2) modulating influence of the medial prefrontal cortex on the lateral hypothalamus is mediated not only by dopaminergic but also by serotoninergic axons. It is suggested that both mechanisms may underlie the phenomenon under study.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0044-4677
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1124-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Lysergic acid diethylamide blockade of the brain serotoninergic receptors prevents the facilitating effect of phenamine on self-stimulation in rats with destruction of the medial prefrontal cortex].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract