rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5203
|
pubmed:dateCreated |
1995-4-6
|
pubmed:databankReference |
|
pubmed:abstractText |
Pineal opsin (P-opsin), an opsin from chick that is highly expressed in pineal but is not detectable in retina, was cloned by the polymerase chain reaction. It is likely that the P-opsin lineage diverged from the retinal opsins early in opsin evolution. The amino acid sequence of P-opsin is 42 to 46 percent identical to that of the retinal opsins. P-opsin is a seven-membrane spanning, G protein-linked receptor with a Schiff-base lysine in the seventh membrane span and a Schiff-base counterion in the third membrane span. The primary sequence of P-opsin suggests that it will be maximally sensitive to approximately 500-nanometer light and produce a slow and prolonged phototransduction response consistent with the nonvisual function of pineal photoreception.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0036-8075
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
10
|
pubmed:volume |
267
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1502-6
|
pubmed:dateRevised |
2010-11-18
|
pubmed:meshHeading |
pubmed-meshheading:7878470-Amino Acid Sequence,
pubmed-meshheading:7878470-Animals,
pubmed-meshheading:7878470-Avian Proteins,
pubmed-meshheading:7878470-Base Sequence,
pubmed-meshheading:7878470-Biological Evolution,
pubmed-meshheading:7878470-Brain Chemistry,
pubmed-meshheading:7878470-Chickens,
pubmed-meshheading:7878470-Cloning, Molecular,
pubmed-meshheading:7878470-Molecular Sequence Data,
pubmed-meshheading:7878470-Nerve Tissue Proteins,
pubmed-meshheading:7878470-Pineal Gland,
pubmed-meshheading:7878470-Protein Structure, Secondary,
pubmed-meshheading:7878470-RNA, Messenger,
pubmed-meshheading:7878470-Retina,
pubmed-meshheading:7878470-Rod Opsins,
pubmed-meshheading:7878470-Sequence Homology, Amino Acid
|
pubmed:year |
1995
|
pubmed:articleTitle |
Pineal opsin: a nonvisual opsin expressed in chick pineal.
|
pubmed:affiliation |
Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|