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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1995-4-4
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pubmed:databankReference |
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pubmed:abstractText |
Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage the microvilli and subapical cytoskeleton of epithelial cells. Here we report finding in EPEC a 35-kbp locus containing several regions implicated in formation of these lesions. DNA probes throughout this locus hybridize to E. coli O157:H7 and other pathogens of three genera that cause similar lesions but do not hybridize to avirulent members of the same species. The EPEC locus and a different virulence locus of uropathogenic E. coli insert into the E. coli chromosome at the identical site and share highly similar sequences near the point of insertion.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-1317383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-1396556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-1433251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-1552854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-1653224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-1682258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-1712012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-1765120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-1937746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-1937792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-2160428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-2172966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-2407656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-2647635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-2875989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-2999794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-3038334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-3298451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-3543152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-6271452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-6350186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-7507897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-7682992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-8005695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-8104225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-8143135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-8168946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-8376594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-8393004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-8406863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7878036-8500884
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
92
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pubmed:geneSymbol |
eaeA,
eaeB,
sepA,
sepB
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1664-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7878036-Base Sequence,
pubmed-meshheading:7878036-Chromosome Mapping,
pubmed-meshheading:7878036-DNA, Bacterial,
pubmed-meshheading:7878036-DNA Transposable Elements,
pubmed-meshheading:7878036-Enteritis,
pubmed-meshheading:7878036-Epithelium,
pubmed-meshheading:7878036-Escherichia coli,
pubmed-meshheading:7878036-Genes, Bacterial,
pubmed-meshheading:7878036-Molecular Sequence Data,
pubmed-meshheading:7878036-Mutagenesis, Insertional,
pubmed-meshheading:7878036-Restriction Mapping
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pubmed:year |
1995
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pubmed:articleTitle |
A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.
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pubmed:affiliation |
Department of Medicine, Department of Veterans Affairs Medical Center, Baltimore, MD.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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