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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1995-4-3
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pubmed:abstractText |
Choline acetyltransferase (ChAT) activity was measured in discrete areas of rat brain after chronic, unlimited access to self-administration of cocaine. Mean activity of ChAT was reduced by approximately 30% in the nucleus accumbens, both on the last day of cocaine access and after 3 weeks cocaine withdrawal. These data suggest that chronic cocaine exposure might inhibit nucleus accumbens cholinergic neurones which could underlie some of the behavioral effects of cocaine.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
10
|
pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29-32
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7877755-Animals,
pubmed-meshheading:7877755-Choline O-Acetyltransferase,
pubmed-meshheading:7877755-Cocaine,
pubmed-meshheading:7877755-Hypothalamus,
pubmed-meshheading:7877755-Male,
pubmed-meshheading:7877755-Neostriatum,
pubmed-meshheading:7877755-Nucleus Accumbens,
pubmed-meshheading:7877755-Parasympathetic Nervous System,
pubmed-meshheading:7877755-Prefrontal Cortex,
pubmed-meshheading:7877755-Rats,
pubmed-meshheading:7877755-Rats, Wistar,
pubmed-meshheading:7877755-Self Administration
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pubmed:year |
1994
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pubmed:articleTitle |
Choline acetyltransferase activity is reduced in rat nucleus accumbens after unlimited access to self-administration of cocaine.
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pubmed:affiliation |
Human Neurochemical Pathology Laboratory, Clarke Institute of Psychiatry, Toronto, Ont., Canada.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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