|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006556,
umls-concept:C0064239,
umls-concept:C0204727,
umls-concept:C0205314,
umls-concept:C0205409,
umls-concept:C0230664,
umls-concept:C0439097,
umls-concept:C0679058,
umls-concept:C0679622,
umls-concept:C1334043,
umls-concept:C1522642,
umls-concept:C1547348,
umls-concept:C1547699,
umls-concept:C1705241,
umls-concept:C2697616,
umls-concept:C2700640
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1995-4-6
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
A rat brain cDNA library was screened for clones homologous to the recently cloned mouse delta-opioid receptor (DOR-1). Among the clones isolated was Hyp 8-1, a clone with a unique nucleotide sequence capable of encoding a putative protein which is 57-58% identical to the amino acid sequences of the cloned delta, mu and kappa opioid receptors, indicating a close relationship of Hyp 8-1 with the opioid receptor family. Several cDNAs representing possible splice variants of Hyp 8-1 were also isolated. Binding studies of COS-7 cells transfected with clone Hyp 8-1 failed to demonstrate specific binding with several 3H-opioid ligands. In situ hybridization studies indicate that the mRNA for Hyp 8-1 is distributed discretely throughout the rat brain, in an overall pattern which is different from that of several other G-protein-coupled seven transmembrane receptors. Thus, it is likely that the Hyp 8-1 cDNA encodes a novel peptide receptor.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, delta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, kappa,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0169-328X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
37-44
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:7877452-Amino Acid Sequence,
pubmed-meshheading:7877452-Animals,
pubmed-meshheading:7877452-Base Sequence,
pubmed-meshheading:7877452-Blotting, Northern,
pubmed-meshheading:7877452-Brain Chemistry,
pubmed-meshheading:7877452-Cercopithecus aethiops,
pubmed-meshheading:7877452-Cloning, Molecular,
pubmed-meshheading:7877452-Consensus Sequence,
pubmed-meshheading:7877452-DNA, Complementary,
pubmed-meshheading:7877452-Ganglia, Spinal,
pubmed-meshheading:7877452-Ligands,
pubmed-meshheading:7877452-Male,
pubmed-meshheading:7877452-Mice,
pubmed-meshheading:7877452-Molecular Sequence Data,
pubmed-meshheading:7877452-Rats,
pubmed-meshheading:7877452-Rats, Sprague-Dawley,
pubmed-meshheading:7877452-Receptors, Opioid,
pubmed-meshheading:7877452-Receptors, Opioid, delta,
pubmed-meshheading:7877452-Receptors, Opioid, kappa,
pubmed-meshheading:7877452-Receptors, Opioid, mu,
pubmed-meshheading:7877452-Sequence Alignment,
pubmed-meshheading:7877452-Sequence Homology
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned mu, delta, and kappa opioid receptors.
|
|
pubmed:affiliation |
Department of Pharmacology, University of Minnesota Medical School, Minneapolis 55455.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
