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rdf:type |
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lifeskim:mentions |
umls-concept:C0003865,
umls-concept:C0007623,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0021755,
umls-concept:C0026473,
umls-concept:C0030685,
umls-concept:C0034693,
umls-concept:C0038402,
umls-concept:C0077273,
umls-concept:C0086418,
umls-concept:C0181209,
umls-concept:C0301625,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1555707,
umls-concept:C1705851,
umls-concept:C1963578,
umls-concept:C2752151,
umls-concept:C2828366
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pubmed:issue |
6
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pubmed:dateCreated |
1995-4-6
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pubmed:abstractText |
1. It was investigated whether an extract of Tripterygium wilfordii Hook f (TW) inhibits IL-1 production by monocytes and suppresses the development of IL-1-dependent arthritis induced in rats with streptococcal cell wall and adjuvant. 2. TW preferentially inhibited IL-1 alpha and IL-1 beta production by bacterial lipopolysaccharide (LPS)-stimulated human monocytes with IC50 of approximately 1 microgram/ml. 3. Oral administration of TW dose-dependently suppressed joint swelling and structural damage in streptococcal cell wall-induced arthritis (ED50 = 20 mg/kg/day) and in adjuvant-induced arthritis (ED50 = 46 mg/kg/day for developing and 8 mg/kg/day for established arthritis).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0306-3623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1115-22
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7875533-Animals,
pubmed-meshheading:7875533-Arthritis, Experimental,
pubmed-meshheading:7875533-Cell Wall,
pubmed-meshheading:7875533-Cells, Cultured,
pubmed-meshheading:7875533-Depression, Chemical,
pubmed-meshheading:7875533-Dose-Response Relationship, Drug,
pubmed-meshheading:7875533-Drugs, Chinese Herbal,
pubmed-meshheading:7875533-Female,
pubmed-meshheading:7875533-Humans,
pubmed-meshheading:7875533-Interleukin-1,
pubmed-meshheading:7875533-Male,
pubmed-meshheading:7875533-Monocytes,
pubmed-meshheading:7875533-Polysaccharides, Bacterial,
pubmed-meshheading:7875533-Rats,
pubmed-meshheading:7875533-Rats, Inbred Lew,
pubmed-meshheading:7875533-Rats, Sprague-Dawley,
pubmed-meshheading:7875533-Streptococcus,
pubmed-meshheading:7875533-Tripterygium
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pubmed:year |
1994
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pubmed:articleTitle |
Inhibition of IL-1 release from human monocytes and suppression of streptococcal cell wall and adjuvant-induced arthritis in rats by an extract of Tripterygium wilfordii Hook.
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pubmed:affiliation |
Department of Inflammation/Bone Metabolism, Rhône-Poulenc Rorer Central Research, Collegeville, PA 19426.
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pubmed:publicationType |
Journal Article
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