Linked Life Data

7874864

Source:http://linkedlifedata.com/resource/pubmed/id/7874864

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-4-5
pubmed:abstractText
1. The effects of essential fatty acids (gamma-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid), at a dose of 4.8 g/day, given in combination as dietary supplements, on cytokine production were investigated in patients with colorectal cancer. 2. Total serum cytokines--interleukin (interleukin-1 beta, 2, 4 and 6), tumour necrosis factor-alpha and interferon-gamma--were analysed using the enzyme-linked immunosorbent assay technique at different time intervals during the course of essential fatty acid supplementation. 3. Fatty acid uptake and patient compliance were confirmed by a significant increase in serum levels of gamma-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid in all three fractions: tricylglycerol, cholesterol and phospholipid. 4. There was no significant alteration in total serum cytokine concentration/levels in the first 2 months of essential fatty acid ingestion, but the levels of serum cytokines steadily declined thereafter, reaching minimum levels after 6 months of essential fatty acid supplementation. 5. Essential fatty acids, at the dose and duration (6 months) used in this study, reduced total serum interleukin-1 beta levels by 61% (P = 0.044), interleukin-2 by 63% (P = 0.05), interleukin-4 by 69% (P = 0.025), interleukin-6 by 83% (P = 0.030), tumour necrosis factor-alpha by 73% (P = 0.040) and interferon-gamma by 67% (P = 0.050). 6. Three months after cessation of essential fatty acid intake, however, these cytokine levels returned to presupplementation values. 7. This present study has shown that long-term n-3 and n-6 EFA ingestion results in a significant reduction in circulating key cytokines. The precise mechanism of this reduction is unclear.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0143-5221
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
711-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:7874864-Aged, pubmed-meshheading:7874864-Aged, 80 and over, pubmed-meshheading:7874864-Colorectal Neoplasms, pubmed-meshheading:7874864-Cytokines, pubmed-meshheading:7874864-Docosahexaenoic Acids, pubmed-meshheading:7874864-Eicosapentaenoic Acid, pubmed-meshheading:7874864-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:7874864-Fatty Acids, Essential, pubmed-meshheading:7874864-Female, pubmed-meshheading:7874864-Humans, pubmed-meshheading:7874864-Interferon-gamma, pubmed-meshheading:7874864-Interleukin-1, pubmed-meshheading:7874864-Interleukin-2, pubmed-meshheading:7874864-Interleukin-4, pubmed-meshheading:7874864-Interleukin-6, pubmed-meshheading:7874864-Male, pubmed-meshheading:7874864-Middle Aged, pubmed-meshheading:7874864-Tumor Necrosis Factor-alpha, pubmed-meshheading:7874864-gamma-Linolenic Acid
pubmed:year
1994
pubmed:articleTitle
Modulation of cytokine production in vivo by dietary essential fatty acids in patients with colorectal cancer.
pubmed:affiliation
Department of Surgery, Medical School, Aberdeen University, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't