|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006118,
umls-concept:C0017262,
umls-concept:C0027651,
umls-concept:C0185117,
umls-concept:C0332448,
umls-concept:C0431085,
umls-concept:C0806987,
umls-concept:C1441616,
umls-concept:C1515021,
umls-concept:C2603343,
umls-concept:C2911684
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|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1995-4-5
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|
pubmed:abstractText |
Fifty-one brain tumors were studied by immunohistochemical methods. The densities of CD45RO+, CD4(OPD4) and CD8 T cells infiltrating the tumors showed negative correlation with the tumor size and positive correlation with the density of macrophages. The density of Ki-67+ tumor cells rose along with the increase in tumor malignancy and showed positive correlation with the tumor size and negative correlation with the density of CD4 T cells. The CD4/CD8 ratio was 0.853, far lower than the normal ratio and there was also positive correlation between their densities. The above results suggest that the level of Ki-67 expression can objectively reflect the proliferative rate and malignant grade of brain tumors. The CD45RO+, CD4 and CD8 T cells infiltrating brain tumors are able to directly inhibit tumor growth. The macrophages take part indirectly in the immunoresponse against brain tumors by influencing CD4 and CD8 T cells. Brain tumors may inhibit the proliferation and immune function of the CD4 subset.
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pubmed:language |
chi
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0529-5807
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
23
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
267-9
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|
pubmed:dateRevised |
2007-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:7874756-Adolescent,
pubmed-meshheading:7874756-Adult,
pubmed-meshheading:7874756-Aged,
pubmed-meshheading:7874756-Antibodies, Monoclonal,
pubmed-meshheading:7874756-Antigens, CD45,
pubmed-meshheading:7874756-Brain Neoplasms,
pubmed-meshheading:7874756-CD4-CD8 Ratio,
pubmed-meshheading:7874756-Child,
pubmed-meshheading:7874756-Child, Preschool,
pubmed-meshheading:7874756-Female,
pubmed-meshheading:7874756-Humans,
pubmed-meshheading:7874756-Immunohistochemistry,
pubmed-meshheading:7874756-Ki-67 Antigen,
pubmed-meshheading:7874756-Leukocytes, Mononuclear,
pubmed-meshheading:7874756-Macrophages,
pubmed-meshheading:7874756-Male,
pubmed-meshheading:7874756-Middle Aged,
pubmed-meshheading:7874756-Neoplasm Proteins,
pubmed-meshheading:7874756-Nuclear Proteins,
pubmed-meshheading:7874756-T-Lymphocyte Subsets
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|
pubmed:year |
1994
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|
pubmed:articleTitle |
[An immunohistochemical study of Ki-67 expression of brain tumor cells and mononuclear cell subsets infiltrating these tumors].
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|
pubmed:affiliation |
Department of Neuropathology, Tianjin Medical College Hospital.
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|
pubmed:publicationType |
Journal Article,
English Abstract
|
