Linked Life Data

7874028

Source:http://linkedlifedata.com/resource/pubmed/id/7874028

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1995-4-6
pubmed:abstractText
No gamma-interferon production was observed in peripheral blood mononuclear cells (PBMC) cultures from 45 patients living in an endemic area of schistosomiasis in Brazil following in vitro stimulation with schistosomula or adult worm antigens from Schistosoma mansoni (4.9 +/- 24 and 1.0 +/- 3.4 pg/ml, respectively). This immunological abnormality was observed in patients both with a high degree of infection (> or = 400 eggs/g feces) and with a low degree of infection (< 400 eggs/g feces), and was independent of the degree of natural exposure to infection. This absence of gamma-interferon production was antigen specific since high levels of this cytokine were detected in the same patients when their cells were stimulated with PPD (247 +/- 179 pg/ml) or PHA (408 +/- 328 pg/ml). In two of four subjects cured of a previous S. mansoni infection and currently living outside the endemic area, gamma-IFN was produced when their PBMC were stimulated with adult worm antigen (75 +/- 2.5 pg/ml).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0100-879X
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1619-25
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
The absence of gamma-interferon production of S. mansoni antigens in patients with schistosomiasis.
pubmed:affiliation
Serviço de Immunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Brasil.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't