| pubmed-article:7872748 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7872748 | lifeskim:mentions | umls-concept:C0004611 | lld:lifeskim |
| pubmed-article:7872748 | lifeskim:mentions | umls-concept:C0332854 | lld:lifeskim |
| pubmed-article:7872748 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:7872748 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:7872748 | lifeskim:mentions | umls-concept:C0450254 | lld:lifeskim |
| pubmed-article:7872748 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:7872748 | pubmed:dateCreated | 1995-3-24 | lld:pubmed |
| pubmed-article:7872748 | pubmed:abstractText | The aim of this study was to determine the influence of bacteria on the development of anastomotic insufficiency following gastrectomy in the rat. Fifty-seven male Wistar rats were randomly assigned to three groups and subjected to gastrectomy. Group I (n = 20) was orally inoculated with 10(9) Pseudomonas aeroginosa organisms on postoperative day 1. Group II (n = 20) served as the control group. Group III (n = 17) was decontaminated with 320 mg of tobramycin, 400 mg of polymyxin B, and 500 mg of vancomycin per liter of fluid administered from preoperative day 7 to postoperative day 10. Swabs from the oropharynx and rectum were cultured and analyzed daily for gram-positive and gram-negative bacteria. Surviving animals were sacrificed on postoperative day 10. All animals were autopsied immediately following death. Anastomotic insufficiency was defined as a histologically proven transmural defect at the suture line. Along with an effective reduction of pathogenic bacteria colonizing the oropharynx, the rate of anastomotic insufficiency could be reduced significantly, to 6% in decontaminated animals compared with 80% in controls (P < 0.001 by Fisher's exact test). Inoculation of group I animals with P. aeruginosa led to an increase of anastomotic insufficiency up to 95% and a significant increase in mortality (P < 0.05). We conclude that bacteria play a major role in the pathogenesis of anastomotic insufficiency following gastrectomy in the rat. | lld:pubmed |
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| pubmed-article:7872748 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7872748 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7872748 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7872748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7872748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7872748 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7872748 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7872748 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:7872748 | pubmed:author | pubmed-author:SchildbergF... | lld:pubmed |
| pubmed-article:7872748 | pubmed:author | pubmed-author:BarettonGG | lld:pubmed |
| pubmed-article:7872748 | pubmed:author | pubmed-author:GatermannSS | lld:pubmed |
| pubmed-article:7872748 | pubmed:author | pubmed-author:SchardeyH MHM | lld:pubmed |
| pubmed-article:7872748 | pubmed:author | pubmed-author:RauH GHG | lld:pubmed |
| pubmed-article:7872748 | pubmed:author | pubmed-author:KampeBB | lld:pubmed |
| pubmed-article:7872748 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7872748 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:7872748 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7872748 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7872748 | pubmed:pagination | 2564-7 | lld:pubmed |
| pubmed-article:7872748 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7872748 | pubmed:meshHeading | pubmed-meshheading:7872748-... | lld:pubmed |
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| pubmed-article:7872748 | pubmed:meshHeading | pubmed-meshheading:7872748-... | lld:pubmed |
| pubmed-article:7872748 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7872748 | pubmed:articleTitle | Bacteria: a major pathogenic factor for anastomotic insufficiency. | lld:pubmed |
| pubmed-article:7872748 | pubmed:affiliation | Department of Surgery, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany. | lld:pubmed |
| pubmed-article:7872748 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7872748 | lld:pubmed |
