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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1995-3-24
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pubmed:abstractText |
The aim of this study was to determine the influence of bacteria on the development of anastomotic insufficiency following gastrectomy in the rat. Fifty-seven male Wistar rats were randomly assigned to three groups and subjected to gastrectomy. Group I (n = 20) was orally inoculated with 10(9) Pseudomonas aeroginosa organisms on postoperative day 1. Group II (n = 20) served as the control group. Group III (n = 17) was decontaminated with 320 mg of tobramycin, 400 mg of polymyxin B, and 500 mg of vancomycin per liter of fluid administered from preoperative day 7 to postoperative day 10. Swabs from the oropharynx and rectum were cultured and analyzed daily for gram-positive and gram-negative bacteria. Surviving animals were sacrificed on postoperative day 10. All animals were autopsied immediately following death. Anastomotic insufficiency was defined as a histologically proven transmural defect at the suture line. Along with an effective reduction of pathogenic bacteria colonizing the oropharynx, the rate of anastomotic insufficiency could be reduced significantly, to 6% in decontaminated animals compared with 80% in controls (P < 0.001 by Fisher's exact test). Inoculation of group I animals with P. aeruginosa led to an increase of anastomotic insufficiency up to 95% and a significant increase in mortality (P < 0.05). We conclude that bacteria play a major role in the pathogenesis of anastomotic insufficiency following gastrectomy in the rat.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7872748-168487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7872748-1969068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7872748-2407913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7872748-2664203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7872748-2805906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7872748-3033040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7872748-3093089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7872748-5640439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7872748-6337097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7872748-6372481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7872748-6470306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7872748-6767797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7872748-6798070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7872748-7266633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7872748-7406385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7872748-814099
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2564-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7872748-Anastomosis, Surgical,
pubmed-meshheading:7872748-Animals,
pubmed-meshheading:7872748-Bacterial Infections,
pubmed-meshheading:7872748-Colony Count, Microbial,
pubmed-meshheading:7872748-Male,
pubmed-meshheading:7872748-Polymyxins,
pubmed-meshheading:7872748-Random Allocation,
pubmed-meshheading:7872748-Rats,
pubmed-meshheading:7872748-Rats, Wistar,
pubmed-meshheading:7872748-Stomach,
pubmed-meshheading:7872748-Tobramycin,
pubmed-meshheading:7872748-Vancomycin
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pubmed:year |
1994
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pubmed:articleTitle |
Bacteria: a major pathogenic factor for anastomotic insufficiency.
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pubmed:affiliation |
Department of Surgery, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.
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pubmed:publicationType |
Journal Article
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