Linked Life Data

7870386

Source:http://linkedlifedata.com/resource/pubmed/id/7870386

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-3-28
pubmed:abstractText
Effects of a brief high-frequency stimulation or a prolonged low-frequency stimulation in the presence and absence of nicotine were studied in thin transverse slices of the dentate gyrus prepared from the guinea pig. Test and conditioning stimulations were delivered to the middle one-third of the molecular layer, and the slope of the population excitatory postsynaptic potentials (EPSPs) elicited by the test stimulation was taken as an indicator of potentiation or depression. Nicotine was without effects on the N-methyl-D-aspartate (NMDA) component of EPSPs at 50 or 100 microM. A brief high-frequency stimulation induced long-term potentiation (LTP) in the presence of bicuculline. Nicotine (50 microM) almost doubled the magnitude of LTP. In the absence of bicuculline, an identical high-frequency stimulation induced a brief depression, the duration and magnitude of which were increased by nicotine. The increase was not statistically significant, however. In contrast to observations in the region CA1, 720 pulses at 1 Hz delivered after induction of LTP failed to induce long-term depression. Nicotine did not modify the after-effect of the low-frequency stimulation. It was discussed that the facilitation of LTP by nicotine probably resulted from suppression of inhibitory processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0168-0102
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
323-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Long-term potentiation and depression in the dentate gyrus, and effects of nicotine.
pubmed:affiliation
Department of Physiology, Faculty of Medicine, Kanazawa University, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't