Linked Life Data

7869893

Source:http://linkedlifedata.com/resource/pubmed/id/7869893

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-3-24
pubmed:abstractText
We propose a compartmental model to explain the signal enhancement curves following the bolus injection of Gd-DTPA. The model incorporates vascular volume fraction contribution, and the possibility of having different transport constants between the plasma and extravascular components. A Walker 256 carcinoma grown in rat muscle was used to demonstrate the capability of this model. Several different types of tissues were included in the measurements: normal, quickly enhanced, slowly enhanced, and necrotic tissues. Blood volume and blood-tissue permeability information can be derived from the dynamic contrast-enhanced MRI study employing the proposed model. In the tissue contrast enhancement curve, the initial rising slope after injection is related to the blood volume (or, vascular volume fraction), the maximum enhancement ratio is related to the uptake of tissue, and the decay rate is related to the clearance of tracer from tissue. The measured permeability constant is not the conventional permeability; instead they are contrast agents uptake and clearance rates, which are limited by the blood perfusion. These parameters can be used to characterize different enhancement patterns.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0740-3194
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
714-24
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Measurement of vascular volume fraction and blood-tissue permeability constants with a pharmacokinetic model: studies in rat muscle tumors with dynamic Gd-DTPA enhanced MRI.
pubmed:affiliation
Department of Radiological Sciences, University of California, Irvine 92717.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.