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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-3-24
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pubmed:abstractText |
Injury to cardiac myocytes often leads to the production of anti-myosin antibodies. While these antibodies are a marker of myocardial injury, their contribution to pathogenesis in diseases such as autoimmune myocarditis or rheumatic fever is much less clear. We demonstrate in this report that monoclonal anti-myosin antibodies can mediate myocarditis in a susceptible mouse strain. Additionally, we show disease susceptibility depends on the presence of myosin or a myosin-like molecule in cardiac extracellular matrix. This study demonstrates that susceptibility to autoimmune heart disease depends not only on the activation of self-reactive lymphocytes but also on genetically determined target organ sensitivity to autoantibodies.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-1311095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-13829493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-13902071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-1577481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-1597350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-1705029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-1918949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-2034131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-2174356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-2189035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-2258609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-3004227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-3005402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-3024549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-3030591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-3034991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-3455232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-3680946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-3875631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-4008636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-4050699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-6244737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-6288291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-7419593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-7504694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-8287498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-8433554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7869033-8482854
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
181
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1123-31
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7869033-Animals,
pubmed-meshheading:7869033-Antibodies, Monoclonal,
pubmed-meshheading:7869033-Autoantibodies,
pubmed-meshheading:7869033-Autoimmune Diseases,
pubmed-meshheading:7869033-Base Sequence,
pubmed-meshheading:7869033-Extracellular Matrix Proteins,
pubmed-meshheading:7869033-Immunoglobulin G,
pubmed-meshheading:7869033-Mice,
pubmed-meshheading:7869033-Mice, Inbred BALB C,
pubmed-meshheading:7869033-Mice, Inbred DBA,
pubmed-meshheading:7869033-Mice, SCID,
pubmed-meshheading:7869033-Molecular Sequence Data,
pubmed-meshheading:7869033-Myocarditis,
pubmed-meshheading:7869033-Myosins,
pubmed-meshheading:7869033-Species Specificity
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pubmed:year |
1995
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pubmed:articleTitle |
Antibody-mediated autoimmune myocarditis depends on genetically determined target organ sensitivity.
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pubmed:affiliation |
Albert Einstein College of Medicine, Bronx, New York 10461.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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