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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1995-3-24
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pubmed:abstractText |
Elevated levels of shear stress such as those that occur in stenotic arterial vessels can directly activate and aggregate platelets and thus contribute to the pathogenesis of acute arterial thrombosis. This shear-induced platelet aggregation (SIPA) is mediated by von Willebrand factor binding to platelet membrane glycoprotein (GP) Ib and GPIIb/IIIa. The chimeric Fab fragment of the monoclonal antibody 7E3 (c7E3 Fab) that binds selectively to GPIIb/IIIa is under clinical evaluation in patients undergoing percutaneous transluminal coronary angioplasty (PTCA). This study was undertaken to investigate the effects on ex vivo SIPA of c7E3 Fab administered to patients undergoing PTCA.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-7322
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1427-31
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7867183-Angioplasty, Balloon, Coronary,
pubmed-meshheading:7867183-Antibodies, Monoclonal,
pubmed-meshheading:7867183-Aspirin,
pubmed-meshheading:7867183-Coronary Disease,
pubmed-meshheading:7867183-Female,
pubmed-meshheading:7867183-Flow Cytometry,
pubmed-meshheading:7867183-Hemorheology,
pubmed-meshheading:7867183-Heparin,
pubmed-meshheading:7867183-Humans,
pubmed-meshheading:7867183-Immunoglobulin Fab Fragments,
pubmed-meshheading:7867183-Injections, Intravenous,
pubmed-meshheading:7867183-Male,
pubmed-meshheading:7867183-Middle Aged,
pubmed-meshheading:7867183-Platelet Aggregation,
pubmed-meshheading:7867183-Platelet Aggregation Inhibitors
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pubmed:year |
1995
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pubmed:articleTitle |
Shear-induced platelet aggregation is inhibited by in vivo infusion of an anti-glycoprotein IIb/IIIa antibody fragment, c7E3 Fab, in patients undergoing coronary angioplasty.
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pubmed:affiliation |
Cox Laboratory for Biomedical Engineering, Rice University, Houston, Tex 77251-1892.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Clinical Trial, Phase I
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