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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-3-27
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pubmed:abstractText |
The uptake of [3H]5-HT and the density (Bmax) as well as affinity (Kd) of 5-HT uptake sites labelled with [3H]paroxetine and of 5-HT2 receptors labelled by [3H]LSD were determined in platelets from 25 medication-free patients with major depression and 20 normal controls. The density (Bmax) of 5-HT2 receptors was found to be significantly increased (by 52%) in platelets from depressed patients, particularly females. No changes were found in the affinity (Kd) of 5-HT2 receptors and in 5-HT uptake or [3H]paroxetine binding parameters. Density of 5-HT2 receptors positively correlated with that of [3H]paroxetine sites in control but not in depressed subjects. No correlation was found between the HAMD scores and Bmax of [3H]LSD binding. The results suggest that upregulation of platelet 5-HT2 receptors is a useful biological marker in major depression, particularly in females.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-1376106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-1498865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2137177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2224370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2310804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2378926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2392511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2537613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2561683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2729424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2831076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2841696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2844132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2927243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2930807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2935409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2959699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2976947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-2981127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-3003804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-3365460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-3573979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-3683087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-3922987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-3931142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-6130248,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-7250184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-7316677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-7384806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-7684072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-8148368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-8248854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-8329169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-8348328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-958421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-971028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7865496-98070
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1180-4882
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7865496-Adolescent,
pubmed-meshheading:7865496-Adult,
pubmed-meshheading:7865496-Biological Markers,
pubmed-meshheading:7865496-Blood Platelets,
pubmed-meshheading:7865496-Depressive Disorder,
pubmed-meshheading:7865496-Female,
pubmed-meshheading:7865496-Humans,
pubmed-meshheading:7865496-Lysergic Acid Diethylamide,
pubmed-meshheading:7865496-Male,
pubmed-meshheading:7865496-Middle Aged,
pubmed-meshheading:7865496-Paroxetine,
pubmed-meshheading:7865496-Radioligand Assay,
pubmed-meshheading:7865496-Receptors, Serotonin,
pubmed-meshheading:7865496-Sex Factors,
pubmed-meshheading:7865496-Up-Regulation
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pubmed:year |
1995
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pubmed:articleTitle |
Serotonergic markers in platelets of patients with major depression: upregulation of 5-HT2 receptors.
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pubmed:affiliation |
Department of Psychiatry, University of Ottawa, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
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